Society supported symposium at Experimental Biology 2018 - DAMPs and Inflammasomes: A Clear and Present Danger

25 April 2018

San Diego Convention Center, Room 23, San Diego, United States

13.30 – 15.00

Chair: Raheela Khan, University of Nottingham, UK

Jointly sponsored by the APS.

The discovery of inflammasomes at the turn of the century is arguably one of the most significant findings in the field of immunology as attested to by the explosion of research papers addressing all aspects of inflammasome biology. The basis of inflammasome activation involves coupling between immunological and physiological pathways. The mechanisms whereby typically harmless molecules turn into danger signals is a fascinating area of research, made even more so by the numerous pathophysiologies in which DAMPs and inflammasomes are implicated.


Unconventional roles for gasdermin D in pyroptosis-independent IL-1b release from neutrophils during inflammasome signalling
George Dubyak, Case Western Reserve University School of Medicine, USA

Inflammasomes beyond IL-1 and cell death.
Vijay Rathinam, University of Connecticut Health, School of Medicine, USA

Alpaca nanobodies reveal mechanistic details of DAMP-induced inflammasome signaling.
Florian Schmidt, University of Bonn, Germany


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