Postdoctoral Position

Location

University of Strathclyde, Glasgow
Closing date: 
04 December 2017
Contact: 
Prof John McCarron

Postdoctoral Position in Vascular Biology

Applications are invited for a post-doctoral position funded by the British Heart Foundation to study endothelial Ca2+ signalling in small arteries in hypertension. The successful applicant will join a well-funded and equipped lab carrying out endothelial imaging using novel imaging methods and analyses to address fundamental problems in vascular physiology1-6.

The endothelium controls virtually every cardiovascular function and changes in the behaviour of the cells underlie almost all cardiovascular disease. The overall objective of the project is to visualise and quantify the signalling patterns that occur in endothelial cells and the changes in signalling associated with disease. Different endothelial cells sense different stimuli and those cells sensitive to particular stimuli are clustered in close groupings. While different cells sense different stimuli, cells communicate so that when multiple stimuli arrive simultaneously each signal input modifies the response of the other cells and clusters even if these are not specifically sensitive to the stimuli. We are interested now in understanding precisely how the cells and clusters communicate with each other and what goes wrong with the communication in hypertension. The project will visualise and quantify the Ca2+ signalling patterns, ROS activity and the mitochondrial behaviour that control all vascular function and their subsequent breakdown in disease, specifically in hypertension.

The successful applicant will apply large-scale and high-resolution imaging and custom-designed analysis approaches to understand how the endothelium coordinates vascular function in intact blood vessels. We welcome applicants from a wide range of backgrounds although some experience in imaging or vascular biology would be an advantage. Where required, the successful applicant will receive training in imaging, image analysis, electrophysiology and myography.

You will have, or soon expect to have, a PhD or similar experience in one or more areas covering of endothelial or vascular biology or optical imaging.  An interest in interdisciplinary research, involving and willingness to communicate across traditional scientific boundaries is vital as these posts involve collaboration with cross disciplinary partners beyond the core team. 

The post is available immediately and will be offered on a fixed-term contract initially for 2 years.  Informal enquiries to Prof John McCarron (john.mccarron@strath.ac.uk; phone 44 (0)141 548 4119) or Dr Calum Wilson (44 (0)141 548 4976; c.wilson@strath.ac.uk), Starting salary will be in the range £31,604-£33,518 depending on experience.

Applications should be made online via Strathclyde University website (at https://www.strath.ac.uk/workwithus/vacancies/  reference 96164 by 30th November 2017 and should include a CV, e-mail addresses of three referees, and a cover letter describing your experience as it relates to the job specification (please make a single file containing letter and CV in .doc, .docx, .pdf, .rtf, .txt or .wps format).

REFERENCES 

1          Wilson, C., Saunter, C.D., Girkin, J.M. & McCarron, J.G. Clusters of specialized detector cells provide sensitive and high fidelity receptor signaling in intact endothelium. Faseb J. 30, 2000-2013, doi:doi:10.1096/fj.201500135 (2016).

2          Wilson, C., Saunter, C. D., Girkin, J. M. & McCarron, J. G. Pressure-dependent regulation of Ca2+ signaling in the vascular endothelium. J Physiol 593, 5231–5253, doi:10.1113/JP271157 (2015).

3          Chalmers, S., Saunter, C. D., Girkin, J. M. & McCarron, J. G. Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle. J Physiol 594, 4283-4295, doi:10.1113/JP271942 (2016).

4          Chalmers, S., Saunter, C. D., Girkin, J. M. & McCarron, J. G. Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension. Nature Scientific Reports 30, 2000-2013, doi:10.1038/srep16875 (2015).

5          McCarron, J. G., Lee, M. D. & Wilson, C. The Endothelium Solves Problems That Endothelial Cells Do Not Know Exist. Trends Pharmacol Sci 38, 322-338, doi:10.1016/j.tips.2017.01.008 (2017).

6          Wilson, C., Lee, M. & McCarron, J. G. Acetylcholine released by endothelial cells facilitates flow-mediated dilatation. J Physiol 594, 7267–7307, doi:doi:10.1113/JP272927 (2016).

7          Wilson C., S. C. D., Gikin J.M., McCarron, J. G. Advancing age decreases pressure-sensitive modulation of calcium signaling in the endothelium of intact and pressurized arteries J. Vasc Res 53, 358–369, doi:10.1159/000454811 (2017).