Experimental models in physiology

27 June 2018 - 29 June 2018

University of Exeter, Exeter, United Kingdom


Wednesday, 27 June

The mighty mouse and the might of other models

9.00 Plenary lecture: The Hedgehog Signalling pathway: insights from flies and fish
Philip Ingham, University of Exeter, UK

10.00 Refreshments

The applicability of rodent models for physiology

10.30 How much less would we understand about human physiology if we didn’t use the mouse as a research model?
Elizabeth Cartwright, The University of Manchester, UK

11.00 Of mice, rats and men: using rodent models and human stem cell models to understand cellular and behavioural deficits in monogenic neurodevelopmental disorders
David Wyllie, University of Edinburgh, UK

11.30 Debate

12.00 Lunch 

12.45 Oral communications

14.15 Refreshments

Complementary models 1

14.30 The fish within – remodelling the pharynx in development and evolution
Anthony Graham, King’s College London, UK

15.00 Birds as model systems to understand the evolution of physiological control of behaviour
Tom Smulders, Newcastle University, UK

15.15 Modelling the insect flight motor using in vivo, time-resolved microtomography
Simon Walker, University of Leeds, UK

15.30 Sodium nitroprusside prevents glucose-induced impairment of cerebrovascular development and function in zebrafish
Tim Chico, University of Sheffield, UK

16.00 Poster session

17.30 Keynote lecture: Fish as models for extreme cardiac (patho)physiology
Stuart Egginton, University of Leeds, UK 

18.30 End of day one


Thursday, 28 June

Pathophysiological models: Cells to complex systems

9.00 Plenary lecture: A systems approach to skeletal muscle adaptation
Claire Stewart, Liverpool John Moores University, UK

10.00 Refreshments

Complementary models 2

10.30 Replicating human disease in rodents: the good and the bad of CRISPR/Cas9 genome editing
Guillaume Pavlovic, PHENOMIN-ICS, France

11.00 A quantitative systems pharmacology approach to understanding drug mechanisms of action
Emily Roashan, University of Reading, UK

11.15 Seasonal and circadian contributions to mental health and wellbeing in the UK Biobank cohort
Laura Lyall, University of Glasgow, UK

11.30 Computational modelling
Jeroen Jeneson, University of Groningen, Netherlands 

12.00 Lunch
Workshop: My local AWERB - what's in it for me?
Penny Hawkins and Maggy Jennings, RSPCA, UK

12.45 Oral communications

14.15 Refreshments

14.30 Kevin Maloy, University of Oxford, UK

15.00 Cardiovascular & renal disease insights from the rat
Robert Menzies, University of Edinburgh, UK 

15.15 Using zebrafish to model joint physiology in development, ageing and disease
Chrissy Hammond, University of Bristol, UK

15.30 Alan Stitt, Queen’s University Belfast, UK 

16.00 Poster session 

17.30 Keynote lecture 
Godfrey Smith, University of Glasgow, UK

19.00 Conference dinner


Friday, 29 June

Future directions: Towards human models

9.00 Plenary lecture: Towards human kidneys in culture: the power and limitations of self-organization
Jamie Davies, University of Edinburgh, UK 

10.00 Refreshments

10.15 Cutaneous photoageing: Systems for modelling repair of human skin
Rachel Watson, University of Manchester, UK

10.45 Exploring the regulation of materno-fetal resource allocation and its implication for development, physiology and disease
Amanda Sferruzzi-Perri, University of Cambridge, UK 

11.15 In vitro modelling of respiratory infection in cystic fibrosis related diabetes
Emily Mavin, Newcastle University, UK 

11.45 Humanized mice to investigate neurodegenerative diseases
Edgar Kramer, University of Plymouth, UK

12.15 BBQ lunch and early career networking