How is skeletal muscle carbohydrate and fat selection regulated in humans?

Metabolism & EndocrinologyMetabolism & Endocrinology (ME)

Organised by Paul Greenhaff and Francis Stephens (University of Nottingham, UK)

We still do not know the intracellular events that regulate the relative contribution of carbohydrate and fat to mitochondrial ATP production in human skeletal muscle at rest and during acute exercise. Furthermore, the mechanisms by which skeletal muscle fuel selection and insulin sensitivity adapt to chronic exercise training, nutritional interventions, and metabolic disease states, such as obesity and type 2 diabetes, have not yet been fully elucidated. Focussing principally on human volunteer studies, this symposium will highlight contemporary data focussed on mechanisms controlling muscle fuel selection during exercise, nutritional intervention and insulin resistance.

Skeletal muscle lipid metabolism in exercise and insulin resistance
Bente Kiens, University of Copenhagen, Denmark
Skeletal muscle carnitine availability in exercise and insulin resistance
Paul Greenhaff, University of Nottingham, UK
Regulation of skeletal muscle carbohydrate oxidation at the level of pyruvate dehydrogenase
Kostas Tsintzas, University of Nottingham, UK
Mechanisms through which exercise enhances mitochondrial function, lipid tolerance and insulin sensitivity
Deborah Muoio, Duke University, Durham, USA
Adaptations of skeletal muscle mitochondrial function to exercise training
Fleming Dela, University of Copenhagen, Denmark
Fuel utilisation, exercise training and skeletal muscle insulin resistance
Jorn Helge, University of Copenhagen, Denmark