Modelling approaches in physiological research

Cross ThemedCross Themed (CT)

Organised by Mary Diaz and Matthew Bailey (University of Edinburgh, UK)

The last decade has seen rapid development and demand for vertebrate and non-vertebrate models of human disease. This symposium focuses on current and future uses of animal models to advance physiology and pathophysiology, particularly in the areas of cardiovascular diseases and related risk factors. We welcome scientists actively engaged in developing and validating such models, encompassing studies in drosophila and zebra fish through to genetic manipulation in rodents.  The speakers will discuss the latest research developments and highlight the current and future approaches, and range of essential ancillary disciplines required to advance our understanding of human physiology and pathophysiology.

Understanding human heart disease: Polygenic and diabetic cardiomyopathy models in Drosophila
Rolf Bodmer (Sanford-Burnham Institute for Medical Research, USA)
Physiological genomics and complex disease traits
Allen Cowley Jr (Medical College Wisconsin, USA)
Use of different experimental hypertension models to decipher the intratubular renal renin-angiotensin system
L Gabriel Navar (Tulane University, USA)
Phenotyping of genetically engineered rodent. An underexploited research tool
Alexander Nikitin (Cornell University, USA)
Cardiac remodelling and regeneration from a fish perspective
Holly Shiels (University of Manchester, UK)
New insights from animal models into the central molecular mechanisms that determine salt-resistance vs. salt-sensitivity
Richard Wainford (Boston University, USA)