Rapid actions of aldosterone on epithelial ion transport

Organised by Brian Harvey (Royal College of Surgeons in Ireland, Dublin, RoI)

Aldosterone is most important hormone regulating blood pressure. Its receptor (MR) and regulated sodium ion channel (ENaC) in the distal nephron are drug targets in controlling hypertension. The relatively fast regulation of ENaC and other epithelial membrane transporters by aldosterone is an area of intense interest in the renal and cardiovascular fields given its clinical implications. Rapid aldosterone actions which are transduced via MR are shown to affect novel protein kinase signalling, membrane trafficking, cross-talk with other receptors and genomic responses. This symposium addresses the major controversies and discoveries in the rapid actions of aldosterone regulating epithelial membrane transport.

The regulation of microRNAs by aldosterone and their impact on ENaC
Michael Butterworth (University of Pittsburgh, USA)

Rapid aldosterone actions on ENaC trafficking and cell proliferation via Protein Kinase D
Ruth Dooley (Royal College of Surgeons in Ireland, Dublin, RoI)

Interaction between mineralocorticoid receptor and epidermal growth factor receptor signaling
Claudia Grossmann (Universitätsklinikum Halle, Germany)

Aldosterone regulation of K+ secretion
Jens Leipziger (Aarhus University, Denmark)

The molecular basis of aldosterone regulation of sodium transport in the collecting duct
David Pearce (University of California, San Francisco, USA)

Aldosterone regulated acid-base transport in the collecting duct
Carsten Wagner (University of Zurich, Switzerland)