Proceedings of The Physiological Society

University of Central Lancashire (2002) J Physiol 543P, S222

Communications

Effect of the anthelmintic emodepside on locomotion in C. elegans, and on the somatic muscle of A. suum

K. Amliwala, J. Willson, L. Holden-Dye, A. Harder* and R.J. Walker

Neuroscience Research Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK and *Animal Health, Bayer AG, OP-BIO/RD, Building 6210, 40789 Monheim, Germany

Emodepside is an anthelmintic with a distinct mode of action which may involve a latrophilin receptor (Bernt et al. 1998). Here we report preliminary studies using the nematode Caenorhabditis elegans for behaviour and Ascaris suum for physiology, with the aim of identifying the genetic basis of emodepside action.

The effect of emodepside on a synchronized population of C. elegans (N2 Bristol strain) was determined. Approximately 100 eggs were placed on agar plates containing E. coli (OP50) and either emodepside (100 pM

Where applicable, experiments conform with Society ethical requirements