Proceedings of The Physiological Society

University of Central Lancashire (2002) J Physiol 543P, S238


Altered calcium homeostasis in heart from streptozotocin-induced diabetic rat

N.K. Bracken*, M.A. Qureshi†, W. Winlow*, J. Singh* and F.C. Howarth†

*Department of Biological Sciences, University of Central Lancashire, Preston, UK and †Department of Physiology, FMHS, United Arab Emirates University, Al Ain, United Arab Emirates

  • "Figure 1. A, representative fast time-base recordings of Ca2+ transients in electrically stimulated (1 Hz) ventricular myocytes, superfused with NT at 35

An alteration in calcium (Ca2+) mobilisation is believed to play an important physiological role in diabetes-induced cardiomyopathy (Ha et al. 1999). In this study we have investigated the role of Ca2+ mobilisation in ventricular myocytes from streptozotocin (STZ)-induced diabetic rats compared with age-matched controls. STZ (60 mg kg-1) was administered intraperitoneally (I.P.) to male Wistar rats (250

Where applicable, experiments conform with Society ethical requirements