Proceedings of The Physiological Society

University of Cambridge (2004) J Physiol 555P, C24


Epoxygenase activity in astrocytes is important for maintenance but not initiation of activity-related dilatation of cerebral arterioles in brain slices

T.A. Lovick and B.J. Key *

Departments of Physiology and * Pharmacology, University of Birmingham, Birmingham B15 2TT, UK

Increases in neuronal activity are accompanied by local increases in cerebral blood flow that facilitate increased delivery of nutrients to meet the needs of the active neuropil. It has been suggested that astrocytes act as an intermediary stage in the process of flow-metabolism coupling by releasing vasodilator products of arachidonic acid metabolism from their perivascular end-feet (Harder et al. 2000).

In the present study we have investigated the dynamics of this process in cortical arterioles maintained in situ in brain slices. Coronal slices, 300-350

Where applicable, experiments conform with Society ethical requirements