Proceedings of The Physiological Society

University of Bristol (2005) J Physiol 567P, PC54

Poster Communications

Surgical weight loss and oxidative stress changes in morbidly obese patients

Catoi Galea, Adriana Florinela; Catoi, Cornel; Daicoviciu, Doina; Galea, Romeo Florin; Schlezak, Vlad;

1. Physiology, University of Medicine and Pharmacy, Cluj Napoca, Romania. 2. Pathology, Faculty of Veterinary Medicine, Cluj-Napoca, Romania. 3. Surgery, University of Medicine and Pharmacy, Cluj-Napoca, Cluj, Romania. 4. student, University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Obesity has become a major health problem in developed countries. It is frequently associated with diabetes mellitus, hyperlipidemia, atherosclerosis, hypertension and other co-morbidities. Oxidative stress is increased in obesity and plays an important role in the pathogenesis of obesity-related complications. Weight loss has an important role in reducing the cardiovacular risk factors. The aim of this study was to observe the impact of weight loss on oxidative stress. Twenty morbidly obese patients (12 women and 8 men) who underwent vertical gastroplasty, with the silicone ring, between 2004-2005, were chosen for this study. We determined the lipid peroxidation (malondialdehyde) as indicator of oxidative stress. Ceruloplasmin (using the Ravin method (spectrophotometric method) and hydrogen donor capacity (using 1,1-diphenyl-pictylhydrazyl) were determined as antioxidative defense indicators. These parameters were measured before, 6 months and 1 year after the surgical intervention. Vertical gastroplasty was associated with an important weight loss in all patients. The average of the initial BMI was 49.43±6.8kg m-2 and 1 year after the intervention was 38.45±6.3kg m-2. Lipid peroxidation decreased significantly with the weight reduction (lipid peroxides decreased from 2.51±1.25 nmol ml-1 to 1.35±0.42 nmol ml-1).

Where applicable, experiments conform with Society ethical requirements