Proceedings of The Physiological Society

University College Dublin (2009) Proc Physiol Soc 15, PC72

Poster Communications

Validating the Human Patient Simulator (HPS) as an educational tool: A comparison of the responses to intravenous administration of adrenoceptor agonists with human data.

P. Maskell1, E. Lloyd1, R. J. Helyer1

1. Department of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.


The Human Patient Simulator (HPS) (HPS 337; METI, Sarasota, Florida) is a high fidelity mannequin controlled by computer software. We have previously shown how the HPS can be used to demonstrate sympathetic and parasympathetic control of the cardiovascular system. (Maskell et al. 2008). The aim of this study was to compare the response of the HPS to the simulated intravenous administration of the adrenoceptor agonists, noradrenaline, adrenaline and isoprenaline with published Human data (Allwood et. al. 1963) in order to validate the HPS as an educational tool for teaching cardiovascular physiology. Baseline measurements were made of heart rate (HR), systolic (SBP), diastolic (DBP), mean arterial (MAP) blood pressure and peripheral vascular resistance (PVR). The responses were determined to the simulated intravenous administration of each of the three adrenoceptor agonists. They were infused at doses of 10mg/min for 15 minutes. Measurements of the variables were made at intervals of five seconds. The infusion of noradrenaline resulted in appropriate increases in SBP, DBP, MAP and PVR but did not produce an appropriate decrease in HR. The infusion of adrenaline resulted in appropriate changes in HR, SBP, MAP and PVR but did not produce an appropriate decrease in DBP. The infusion of isoprenaline resulted in appropriate changes in HR and PVR but did not produce appropriate changes in SBP, DBP or MAP. We conclude that the HPS is a potential tool for demonstrating responses to the adrenoceptor agonists noradrenaline, adrenaline and isoprenaline, but further work is required to improve the software pharmacodynamic and baroreceptor to improve the validity of the HPS as an educational tool.

Where applicable, experiments conform with Society ethical requirements