Proceedings of The Physiological Society
AstraZeneca (2010) Proc Physiol Soc 18, PC23
Preclinical studies on the effect of ethanolic extract of ginger on the renal antioxidant enzyme system and hormonal regulation in STZ-induced diabetic male albino rats
S. Kesireddy1, S. Kondeti Ramudu1, M. Korivi1,2
1. Zoology, sri Venkateswara University, Tirupati, andhra Pradesh, India. 2. Laboratory of Exercise Biochemistry, Taipei Physical Education College, Taipei, Taiwan.
Diabetes is a major socio-economical burden with serious health consequences(1). The reactive oxygen species generated in this pathology alters the internal milieu of the cellular systems paving way for metabolic disorders(2,3). The aim of the present study was to evaluate the effect of the ethanolic extract of ginger rhizome on oxidative stress in relation to hormonal regulation in kidney of streptozotocin (STZ) induced diabetic rats. The parameters like superoxide dismutase (SOD) activity, ascorbic acid (vitamin C), alpha tocopherol (vitamin E) levels, calcitriol, renin were decreased and uric acid level, glutathione-s transferase (GST), xanthine oxidase (XOD) activity were increased in diabetic control rats. Ginger treatment (30 days) remarkably improved the tissue antioxidant defense system and all the above parameters attained near normality after treatment with ginger in STZ-diabetic rats. On the basis of the results obtained, it is concluded that the treatment of ginger may effectively normalize the impaired oxidative stress in response to hormonal changes in streptozotocin-induced diabetes than the glibenclamide-treated groups. Moreover, degenerative changes of renal cells in the diabetic group were minimized by the administration of ginger as shown by histopathological examination. Based on these findings, it is suggested that consumption of ginger is beneficial in terms of defensive action against oxidative stress.
Where applicable, experiments conform with Society ethical requirements