Proceedings of The Physiological Society
University College London December 2005 (2006) Proc Physiol Soc 1, PC1
Cortico-cortical interactions in motor and premotor cortex of macaque monkeys investigated with chronically implanted microarrays: effects of ICMS and transient inactivation with muscimol
Schmidlin, Eric; Brochier, Thomas; Den Ouden, Hanneke; Maier, Marc; Lemon, Roger N;
1. Neurology, UCL, London, United Kingdom.
One of the distinguishing features of the ventral premotor cortex (area F5) is that low-threshold repetitive intracortical microstimulation (rICMS) evokes digit movements. We investigated whether these motor effects result from a direct influence upon the spinal networks controlling digit movements or upon cortico-cortical connections with the primary motor cortex (M1). We evoked digit movements from F5 or M1 using small arrays of low impedance chronically implanted microwires and then tested whether these motor responses were affected by local microinjections of the GABAA agonist muscimol into the hand area of M1. Two macaque monkeys were used. The hand area in both F5 and M1 were first localised using structural MRI and subsequent mapping of both areas using rICMS at low threshold (< 10
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