Proceedings of The Physiological Society

University College London December 2005 (2006) Proc Physiol Soc 1, PC26

Poster Communications

Prior disruption of bloodbrain barrier integrity compounds hypoxic headache; exercise, heat and free radicals as 'vasogenic primers'

Bailey, Damian Miles; Ainslie, Philip N; Evans, Kevin A; Hullin, David A; Bartsch, Peter;

1. Department of Physiology, University of Glamorgan, Pontypridd, United Kingdom. 2. Department of Physiology, University of Otago, Dunedin, New Zealand. 3. Department of Medical Biochemistry, Royal Glamorgan Hospital, LLantrisant, United Kingdom. 4. Department of Sports Medicine, University of Heidelberg, Heidelberg, Germany.

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  • Table 1. Neuro-metabolic responses to hypoxia following prior exposure to heat and exercise
    Values are means

Using a combination of exercise and heat stress, the present study examined whether prior disruption of bloodbrain barrier (BBB) integrity in normoxia would alter individual susceptibility to neurovascular headache initiated during subsequent exposure to inspiratory hypoxia. Eleven males aged 24

Where applicable, experiments conform with Society ethical requirements