Proceedings of The Physiological Society
University College London December 2005 (2006) Proc Physiol Soc 1, PC27
Cerebral haemodynamics during exercise and hypoxia; 'downstream' consequences for pulmonary function
Evans, Kevin A; Ainslie, Philip N; Fall, Lewis; Martins, Pedro; Kewley, Emily; Mason, Nicholas P; Bailey, Damian M;
1. Department of Physiology, University of Glamorgan, Pontypridd, United Kingdom. 2. Department of Physiology, University of Otago, Dunedin, New Zealand. 3. Department of Critical Care Medicine, University Hospital of Wales, Cardiff, United Kingdom.
A reduction in cerebral oxygenation may contribute to brain swelling and neurovascular headache (Bailey et al. 2005) which in severe cases may progress to pulmonary oedema. This suggests that remote pulmonary complications may have a neurogenic basis. The present study combined exercise and hypoxia to effect changes in cerebral oxygen (O2) delivery and examined implications for cerebral autoregulation and pulmonary function in individuals susceptible to hypoxic headache (HHS) compared to those who are resistant (HHR). Eighteen males aged 26
Where applicable, experiments conform with Society ethical requirements