Proceedings of The Physiological Society

King's College London (2011) Proc Physiol Soc 22, PC04

Poster Communications

The MRC London neurodegenerative diseases brain bank: a resource for neuroscience research

C. Troakes1, S. Al-Sarraj1

1. London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, King's College London, London, United Kingdom.


Clinically and neuropathologically well-characterised human brain tissue is one of the most important resources for neuroscience research and is essential in the battle to develop new strategies and treatments for neurodegeneration. There has been significant research progress in recent decades and post-mortem tissue has played a major role in enabling advances in diagnosis, characterisation of pathological features, molecular genetics and bioinformatics. The MRC London Neurodegenerative Diseases Brain Bank (LNDBB) is one of the largest brain banks in the UK. Since its establishment in 1989 it has collected over 2000 cases (formalin fixed and frozen samples). We focus our banking on neurodegenerative diseases, including Alzheimer’s disease, Dementia with Lewy Bodies, Motor Neurone Disease and Frontotemporal dementia and age-matched controls but also house smaller collections, such as psychosis and paediatric disorders, in order to enhance research in these areas. The LNDBB operates a transparent and open-door policy for provision of central nervous system tissue to researchers. So far we have completed over 1270 requests and provided over 10,000 samples to national and international institutions. We are part of the MRC UK Brain Banks and Brains for Dementia Research networks which aim to encourage and facilitate both tissue donation and accessibility and use by researchers. The brain bank also carries out studies into the best methods of preservation of tissue and the research potential of archival fixed tissue. We are constantly updating our procedures to ensure tissue is of the best quality for use in current research techniques.

Where applicable, experiments conform with Society ethical requirements