Proceedings of The Physiological Society
University of Oxford (2011) Proc Physiol Soc 23, C107
The effect of short duration high intensity interval exercise on postprandial lipaemia and soluble adhesion molecules.
B. Gabriel1, M. P. Frenneaux1, A. Ratkevicius1, S. R. Gray1
1. Aberdeen University, Aberdeen, United Kingdom.
Seven-hour areas under the plasma concentration over time curve for total triacylglycerol and incremental triacylglycerol (adjusted for fasting values) on the control, walking and high intensity intervals trials.<\#13>
* denotes a significant (P<0.05) difference compared to the control trial, data are presented as mmol/7h.L-1
It has been suggested that atherogenesis is a post-prandial phenomenon (Zilversmit, 1979). Inflammatory processes appear to couple dyslipidaemia to atherosclerotic plaque formation, partially through the induction of the endothelium to express adhesion molecules e.g. ICAM-1 and VCAM-1. Moderate intensity exercise has been shown to attenuate post-prandial lipaemia (Miyashita et al., 2008) (Gill et al., 2004). Recent research has indicated that high intensity interval exercise may enable a variety of health benefits with a reduction in total exercise time (Rakobowchuk et al., 2008), although it’s potential to reduce post-prandial lipaemia is yet to be elucidated. The aim of the present study, therefore, is to determine the effect of high intensity intermittent exercise on post prandial lipaemia and expression of soluble adhesion molecules. Eight men (age; 25±3 years, body fat %; 15.7±3.5) each completed three two day trials in a random order. On day 1: subjects rested (C), walked briskly for 30 mins (W) or performed 5 x 30 sec maximal sprints with 4 min recovery between each sprint (H). On day 2 subjects arrived after an overnight fast and consumed a high fat meal for breakfast and 3h later for lunch. Blood samples were taken at rest, 0.5,1,2,3,3.5,4,5,6 and 7 hours and analysed for triacylglycerol, glucose, insulin, ICAM-1 and VCAM-1. Data were analysed via 2-way ANOVA and post-hoc Tukey’s test. During H there was a lower (P<0.05) total and incremental triacylglycerol area under the curve (AUC) compared to C (Table 1). During W there was no difference in total or incremental AUC when compared to C. There were no differences in adhesion molecules, insulin or glucose between the trials, although sICAM-1 concentration rose throughout the day (P<0.001). High intensity interval exercise attenuates post prandial lipaemia after the consumption of a high fat meal and may be a useful tool to combat the development of atherosclerosis.
Where applicable, experiments conform with Society ethical requirements