Proceedings of The Physiological Society

Physiology 2014 (London, UK) (2014) Proc Physiol Soc 31, PCB071

Poster Communications

Effect of taurine and caffeine on serum C-Reactive protein and calcium in Wistar rats

B. V. Owoyele1, O. Alashi1, L. Oyewole1

1. Department of Physiology, University of Ilorin, Ilorin, Nigeria.

Caffeine is a component of several beverages such as coffee and tea (Sawynok, 2011). It has been shown to possess psychoactive properties because it increases alertness, energy and ability to concentrate at moderate doses. Taurine on the other hand is an amino acid which has the capacity to promote neural development, osmoregulation and neuroprotection ( Marcinkiewicz and Kontny, 2014). There is paucity of information on the effect of the combined administration of taurine and caffeine on c-reactive protein (CRP) - a marker of inflation and calcium level in rats. Therefore the present study was designed to investigate the effects of combined taurne and caffeine on the serum level of CRP, Ca2+ as well as the effect of nifedipine on calcium level. Forty eight rats weighing 120-140g were used for these studies. The animals were divided into eight groups consisting of six animals each. Group 1 was treated with 10 ml/kg of normal saline, Group 2 and 3 were given 100 mg/kg and 200mg/kg of taurine respectively, groups 4 and 5 received 7.5 mg/kg and 15 mg/kg of caffeine respectively while group 6 was administered taurine (200 mg/kg) and caffeine (15 mg/kg), group 7 and 8 were treated with taurine (200mg/kg) plus nifedipine (10mg/kg) and taurine (200mg/kg) plus furosemide (20 mg/kg) respectively. The results showed that CRP was significantly decreased in six of the treated group compared with the control with the exception of the group treated with taurine alone. The Ca2+ level of groups treated with caffeine (11.70 ± 0.29 mg/dL) and taurine with caffeine (11.64 ± 0.15 mg/dL) were significantly (p<0.05) increased compared with the control (10.70 ± 0.29 mg/dL). However, treatment with taurine and nifedipine (Group7) led to significant (p<0.05) reduction in Ca2+ level. In conclusion, these studies have shown that combined caffeine and taurine can boost plasma calcium level and minimized the plasma CRP. The results suggests that the combined drug can increase serum Ca2+ needed for cellular and neurophysiological signaling; and as well as decreasing CRP thus minimizing the chance of cardiovascular diseases. These studies also showed that taurine can effectively decrease both the plasma Ca2+ and CRP level. An effect that is enhanced in rats placed on nifedipine medication thus these studies may help guiding the future research on how to exploit combined taurine shot with Ca2+ blockers in treating severe hypertension cases.

Where applicable, experiments conform with Society ethical requirements