Proceedings of The Physiological Society

Mitochondria: Form and function (London, UK) (2017) Proc Physiol Soc 38, SA09

Research Symposium

Autophagy-mitochondria axis in health in disease

V. I. Korolchuk1

1. Newcastle University, Newscastle, United Kingdom.

Autophagy has multiple cellular functions and is important for the maintenance of proteome, genome and organellar homeostasis. Perturbation of autophagy has been associated with multiple pathologies however it remains unclear how different cellular roles of autophagy contribute to the cellular dysfunction in conditions of autophagy impairment. Our data suggest specific mechanisms by which autophagy deficit and an impairment of mitochondrial quality control by autophagy (mitophagy) may lead to cell death. We use a lysosomal storage disease model characterised by autophagy dysfunction as a proof of principle for the relevance of these mechanisms to human neurodegenerative diseases.

Where applicable, experiments conform with Society ethical requirements