Proceedings of The Physiological Society

Mitochondria: Form and function (London, UK) (2017) Proc Physiol Soc 38, SA12

Research Symposium

Exercise and skeletal muscle mitochondria

F. Amati1

1. University of Lausanne, Lausanne, Switzerland.


Skeletal muscle mitochondria are highly adaptable and respond to exercise training by multiple mechanisms. In humans, exercise modulates the different electron transport chain complexes distinctively. Among the molecular adaptations, exercise favors the shift of free complexes into functional supercomplexes assemblies. Free and superassembled complexes co-exist and are recruited in response to energy demand. The content of supercomplexes is positively related to muscle respiration and exercise efficiency. Other long-term adaptations to exercise include the improvement of mitochondrial quality through mitochondrial turnover and adaptations of mitochondrial dynamics.

Where applicable, experiments conform with Society ethical requirements