Proceedings of The Physiological Society

Future Physiology (Leeds, UK) (2017) Proc Physiol Soc 39, PC01

Poster Communications

Modulatory role of clove and fermented ginger supplements on oxidative stress and lipid peroxidation marker in high fat diet induced type 2 diabetes in rabbits

A. Abdulrazak1,2,2,3

1. Human Physiology Department, Kaduna State University, Kaduna- Nigeria, Kaduna, Kaduna, Nigeria. 2. Department of Human Physiology, Ahmadu Bello University Zaria, Zaria, Kaduna, Nigeria. 3. Department of Human Physiology, Bayero University Kano, Kano, Kano, Nigeria.


This study aimed to evaluate the effects of clove and fermented ginger supplements on oxidative stress biomarkers (SOD and CAT), lipid peroxidation marker (MDA) in high fat diet (HFD) induced type 2 diabetes rabbits. HFD (40% fat dietary content) was fed to rabbits for eleven weeks to ascertain diabetic animal model (DAM) [1, 2]. Thereafter, DAM were treated with supplements for six weeks. Thirty male rabbits ‘Oryctolagus Lilljeborg' (8-10 weeks of age) divided into six groups (n=5) were used. Group I (Normal control) fed on standard animal feed (SAF), Group II-VI were (DAM groups); Group II, fed SAF only, Group III fed SAF + cholestran (0.26 g/kg) [3], Group IV fed SAF + clove buds (12.5%) supplements, Group V fed SAF + fermented ginger (FG) (12.5%), and Group VI fed SAF + clove buds (12.5%) + FG (12.5%). At the end of six weeks treatment period, serum was used for the biochemical assessments. the results revealed a significantly (P < 0.05) decrease in MDA levels (1.1±0.071 nmol/L) in the combined supplements treated group compared to the level (1.54±0.051 nmol/L) in diabetic control, while SOD (2.1±0.07) and CAT (45.8±0.73) significantly increase in the combined supplements treated group compared to the levels SOD (1.6±0.07) and CAT (37.6±0.67) in diabetic control. This indicate a boost in antioxidant enzymes and decreased lipid peroxidation in treated groups [4]. The observed results may be attributed to active constituents in the supplements [5]. Hence, with further validation, they should be considered among valued supplements in ameliorating diabetes pathologies. Keywords: clove, fermented ginger, supplements, Oxidative stress. And Diabetes.

Where applicable, experiments conform with Society ethical requirements