Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCA003

Poster Communications

C-Reactive Protein is Related to Left Ventricular Mass Independent of Co-Morbidities in a Community Sample with a High Prevalence of Risk-Related CRP.

F. MAUNGANIDZE1,2

1. PHYSIOLOGY, MIDLANDS STATE UNIVERSITY, Gweru, Zimbabwe. 2. Physiology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.


  • Bivariate relationships between log C-reactive protein (CRP) concentration and left ventricular mass (LVM) index or inappropriate LVM (LVMinappr) in a community sample.

To determine whether there is a relationship between circulating C-reactive protein (CRP) concentrations and left ventricular mass (LVM) independent of co-morbidities. In 361 randomly selected participants from a community with a high prevalence of CRP concentrations considered to be high-risk (54.0%), but without cardiovascular or renal disease, the relationship between CRP and echocardiographically-determined LVM indexed to height2.7 (LVMI) and inappropriate LVM (LVMinappr) was evaluated. LVMinappr was determined from the % of actual/predicted LVM. Serum CRP concentrations were correlated with both LVMI and LVMinappr (p<0.0001). With adjustments for a number of potential confounders including age, systolic blood pressure, waist circumference (or body mass index), and glucose control (glycated haemoglobin), the relationships between serum CRP concentrations and both LVMI and LVMinappr (partial r=0.11, p<0.05 for both) persisted. The independent relationship between CRP and LVMI or LVMinappr translated into a markedly higher multivariate-adjusted LVMI and LVMinappr values in the highest as compared to the lowest quartile of CRP (LVMI; highest quartile CRP=48.8±10.7, lowest quartile CRP=45.0±11.0, p<0.05; LVMinappr; highest quartile CRP=137±28, lowest quartile CRP=127±24, p<0.02). Previous studies found relationships between CRP and LVM or LVH, but those studies were conducted in select clinical populations or populations with a low prevalence of risk-related CRP concentrations and the relationships were not demonstrated to be independent of co-morbidities. However, in randomly selected participants from a population with a high prevalence of CRP, the CRP concentrations were associated with LVMI or LVMinappr independent of co-morbidities.

Where applicable, experiments conform with Society ethical requirements