Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCA155

Poster Communications

Low amplitude pressures in high resolution manometry

L. Zouiten1,2, A. Laabidi1, M. Serghini1, J. Boubaker1

1. la Rabta Hospital, Tunis, Tunisia. 2. Université de Tunis El Manar, Faculté de Médecine de Tunis, Laboratoire de physiologie,, Tunis, Tunisia.


Aim: to investigate low amplitude pressures defined by distal contractile integral (DCI) <450mmHg/s/cm on high-resolution manometry (HRM)) in ≥50% of test swallows. Materials and methods: We searched retrospectively the database between January 2017 and May 2018 patients having in HRM a DCI<450mmHg/s/cm in ≥50% of test swallows. HRM results were interpreted using the Chicago Classification v3.0. Results: A total of 92 patients (67.4% female) with a mean age of 49 ± 16 years were included. The main presenting symptom at time of manometry study was dysphagia in 50%. The mean of ICD in 10 deglutitions was 176.5mmHg/s/cm. The absence of contractility defined by the DCI < 100 mmHg/s/cm in all swallows was showed in 67% of cases with achalasia (n=40), scleroderma (n= 13), dysphagia (n= 8) and gastroesophageal reflux disease (GERD) (n=1). The ineffective esophageal motility defined by DCI<450mmHg/s/cm in ≥50% of test swallows was observed in 28 patients (30.4%) with 16 patients having absent contraction in more of 50% of deglutitions (7 scleroderma, 7 dysphagia and 2 GERD), 8 patients having weak contractions in > 50% of deglutitions (3 dysphagia, 2 GERD, 1 chest pain, 2 scleroderma) and 1 patient with 100% of deglutitions were weak (GERD). Ineffective esophageal motility with mean of DCI > 450 mmHg/s/cm was observed in10 patients (5dysphagia, 3 GERD and 2scleroderma). Conclusion: Major disorders of peristalsis represented by absent contractility were observed in achalasia and scleroderma and minor disorders of peristaltis represented by ineffective esophageal motility in dysphagia and GERD.

Where applicable, experiments conform with Society ethical requirements