Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCA156

Poster Communications

Sphincters resting pressures in high resolution manometry

L. Zouiten1,2, A. Laabidi1, M. Serghini1, J. Boubaker1

1. la Rabta Hospital, Tunis, Tunisia. 2. Université de Tunis El Manar, Faculté de Médecine de Tunis, Laboratoire de physiologie,, Tunis, Tunisia.

Aim: to evaluate the most appropriate time to measure the resting pressure of the upper esophageal sphincter (UES) and lower esophageal sphincter (LES) during high resolution manometry (HRM). Methods: 70 patients who had HRM between December 2016 and March 2018 are recruited. The solid manometry catheter with 36 circumferential sensors was used. The measurement of resting pressure was done at the beginning and the end of procedures. Results: The mean resting pressure of the UES decreased during HRM (p=0.013). Decreasing in resting pressure of UES was observed in 62.9% of patients and increasing in 35.7% (p<10-4). The difference between time of recording is statistically significant (p<10-4). The correlation between LES pressure and the conclusion of exam was more significant when the pressure is measured in the end of the procedure (p=0.001 vs p<10-4). Hypotonic and hypertonic LES was diagnosis at the beginning of test in 10% and 8.6% respectively and at the end in 13% and 11.4% (p<10-4). No correlation was observed between abnormal resting pressure of UES and LES in the both time of recording. Conclusion: Measuring the basal pressures at the end of the test seems to be the best practice and better reflect the physiological sphincters function with a lesser effect of the vagus nerve in stress situation.

Where applicable, experiments conform with Society ethical requirements