Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCA157

Poster Communications

Esophageal abnormalities in patients with gastro-esophageal reflux disease on high resolution manometry as defined by Chicago classification

A. Laabidi1, L. Zouiten1,2, M. Serghini1, J. Boubaker1

1. la Rabta Hospital, Tunis, Tunisia. 2. Université de Tunis El Manar, Faculté de Médecine de Tunis, Laboratoire de physiologie,, Tunis, Tunisia.

Aim: The aim ofthis study is to characterize esophageal dysmotility in patients with gastro-esophageal reflux disease (GERD) and compare demographic features, clinical symptoms and endoscopic findings across patients with different dysmotility patterns. Methods: Patients with GERD who underwent high resolution manometry at our institution were identified. Data regarding demographic features, clinical symptoms and endoscopic findings were abstracted from medical records. High resolution manometry results were interpreted using the Chicago Classification, v3.0 criteria. Results: A total of 31 patients were colliged. There were 14 males and 17 females with mean age of 56 ±15.2 years. High-resolution esophageal manometry was normal in 22, showed ineffective esophageal motility in 6, absent contractility in 1, fragmented peristalsis in 1 and one case of type I achalasia. Esophagogastric junction (EGJ) resting pressure was within normal range (10 - 45 mmHg) in 23, low (< 10 mmHg) in 6 patients and high (> 45 mmHg) in 1 patient. Dysphagia was significantly more frequently reported in patients with ineffective motility than patients with other dysmotilitypatterns (respectively 66.7% vs 16%; p=0.026). Patients with hiatal hernia were older than patients who had not (respectively 63.5± 6 vs 50.1±15 years; p=0.05). Upper esophageal sphincter pressure was negatively correlated with age (r=0.3; p=0.05). There was no association between endoscopic findings and patterns of motility disorders. Conclusion: The HRM has represented a major advance in defining and characterizing esophageal motility abnormalities in GERD patients. Ineffective esophageal motility is the most common and the most dysphagia-associated motility disorder in patients with gastro-esophageal reflux disease.

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