Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCA201

Poster Communications

Myopenia in Obstructive Pulmonary Disease: an indicator of poor prognosis

K. AYED1, S. RIAHI1, S. MOKADDEM1, A. CHAKER1, K. KCHAOU1, S. JAMELEDDINE1

1. Department of Pulmonary Fonctionnal Testing, ABDERAHMENE MAMI HOSPITAL, Ariana, Ariana, Tunisia.


Background: Muscle Mass (MM) wasting, frequently observed in advanced stages of COPD is currently considered as a major predictor of mortality. Aim: The aim of this study was to investigate possible correlations between MM wasting, severity of airflow limitation and tolerance to sub-maximal physical exertion in a group of COPD patients. Methods: This prospective study included 46 male COPD patients. Slow and forced spirometry, bronchial reversibility test with salbutamol, COPD Assessment Test (CAT), bioelectric impedance measurement and Six-Minute walk Test (6MWT) were performed for all patients. Results: The average values of age and MM were respectively 60 ± 19 years and 35,5 ± 3,8%. Spirometric data revealed that 76% of patients were in stages 3 and 4 of disease (GOLD 2017). Significant correlations (p <0.05) were found between MM and these following parameters: Forced Expiratory Volume in one second (FEV1) post bronchodilator as indicator of severity of airway limitation, difference between Slow and Forced Vital Capacity (SVC - FVC) as indicator of trapping air volume and 6 MWT distance as indicator of global tolerance to physical exertion. Our data revealed also a significant correlation between myopenia and multiparametric BODE index (Body Mass Index, Airflow Obstruction, Dyspnea, Exercise Capacity) as indicator of poor prognosis. Conclusion: Regular assessment of body composition in particular MM should be systematically performed in all COPD patients to ensure early diagnosis of myopenia and to start as soon as possible nutritional management and respiratory rehabilitation.

Where applicable, experiments conform with Society ethical requirements