Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCA253

Poster Communications

The effects of acacia senegal (gum arabic) supplementation on inflammatory marker, renal and hematological profile in hemodialysis patients

N. Elkhair1,2, L. Kaddam3, A. M. Saeed4

1. physiology, AlMughtaribeen University, Khartoum, Sudan. 2. physiology, Nile college, Khartoum, Sudan. 3. physiology, Al-Neelain University, Khartoum, Sudan. 4. physiology, The University of Khartoum, Khartoum, Sudan.

  • Figure I: Effect of Acacia Senegal intake on C-reactive protein (CRP) Level ( P=0.0016)

Several studies observed that heamodialysis patients have serological confirmation of an activated inflammatory response. Inflammation is one of non-traditional risk factor of cardiovasculare disease which is considered as major cause of mortality in end stage renal disease . Causes of inflammation in end stage renal disease are multifactorial, including exposure of blood to dialyzer membranes, infection on vascular access, reduced antioxidants, and increased oxidative stress. Acacia senegal has been claimed to have an anti-inflammatory effects.This study was conducted to investigate the effect of Acacia senegal on inflammatory status in patients on regular hemodialysis. This study was done as phase II clinical trial among patients on regular hemodialysis in Sudan . Forty end stage renal disease patients age (18-80 years) were recruited . Patients took orally 30 g/day GA for 12 weeks. Renal function test (RFT), Complete blood count (CBC ) and C reactive protein (CRP) was measured by an enzyme immunoassay method, all of them were measured monthly .Repeated measures analysis of variance (ANOVA) was used to analyze the data. CRP level was significantly decreased (P =0.0016). Acacia senegal significantly decreased both the level of urea and creatinine ( P=0.0004) and (P =0.049) respectively. And uric acid level significantly reduced (P= 0.0057). Acacia senegal had no effect on serum electrolytes level except the phosphorus which was significantly reduced (P=0.0039). Acacia senegal increased the Hb (P=0.0357) and RBCs count (P=0.0253) significantly without any effect on other hematological parameters . These data suggest that daily supplementation of Acacia senegal (30 g/day) significantly reduced the inflammation in hemodialysis patients .The anti-inflammatory effect of Acacia senegal may have positive impact on other diseases characterized by increase inflammation.

Where applicable, experiments conform with Society ethical requirements