Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCA302

Poster Communications

Effect of cigarette smoking on the nerve conduction study among young adults

R. M. musa1, L. Kaddam1, M. Abdelrahman2, H. Suekit3

1. physiology, AL-Neelain university, KHARTOUM omdurman, KHARTOUM, Sudan. 2. AL-Neelain university, OMDURMAN, Sudan. 3. physiology, International University of Africa, KHARTOUM, Sudan.

Introduction: The effects of cigarette smoking on many organs is well-known. It is recognized as a risk factor for many diseases such as hypertension, ischemic heart diseases, and cancer. However, the effect of cigarette smoking on central and peripheral nervous system is still unclear. The aim of this study was to evaluate the effect of smoking on the nerve conduction study of the median nerve (motor part). Methodology: This study was descriptive institutional based case-control study carried out at AL-Neelain University Faculty of Medicine during 2017. Thirty-one healthy smokers were volunteered to participate and 34 healthy non-smokers were matched and taken as a control. The data were collected using a self-administered questionnaire and the nerve conduction study was measured using power lab serial number G607. The median nerve was stimulated supra-maximally at two points along its course at the wrist and antecubital fossa. Nerve conduction velocity, amplitude, proximal latency and distal latencies were recorded. The data was analyzed using (SPSS) Version 22 and graph pad prism 7. Comparison of means of continuous data between smokers and non-smokers were tested by independent Student t-test. P-value of <0.05 (two-tailed) was used to establish statistical significance Results: The result revealed that healthy smokers had a lower amplitude of nerve conduction study compare to healthy non-smokers (3.1±.08 and 4.9±1.50 respectively, P value =0.000). There was no statistically significant difference in the nerve conduction velocity of smokers and non-smokers (P-value 0.07). Also, there was no statistically significant difference in the proximal and distal latencies between smokers and non-smokers (P value more than 0.05 for both). Conclusion: Early exposure to cigarette smoking attenuates the amplitude of the median nerve. The changes induced by smoking were not related to the duration of smoking and the number of smoked cigarettes per day. Keywords: Smoking, Nerve conduction study, Median nerve

Where applicable, experiments conform with Society ethical requirements