Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCB009

Poster Communications

Comparison of nonlinear and linear heart rate variability parameters in diagnosis of cardiac autonomic neuropathy in patients of multiple system atrophy

A. Singhal1, R. Sharma1, P. H. Kamble1, S. Ravichandran1, Y. Singh2,1

1. Physiology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, Rajasthan, India. 2. Physiology, RKGMC, Hamirpur, India.


Background: The purpose of this study was to compare sensitivity and specificity of Nonlinear and Linear heart rate variability parameters (HRV) in diagnosing cardiac autonomic neuropathy (CAN) in multiple system atrophy (MSA) patients. Methods: Nonlinear (Poincare analysis) and Linear (Time and Frequency domain analysis) HRV parameters were investigated among 35 MSA patients. ROC curve was plotted to compare sensitivity and specificity of individual tests. Ewings Scoring was used as the gold standard for diagnosis of CAN. Results: The area under curve for SD1/SD2, HF and LF/HF ratio is 0.620, 0.453 and 0.424 with 95% confidence interval of 0.417-0.823, 0.248-0.658 and 0.222-0.631 respectively. Time domain parameters had smaller area under curve as compared to Poincare and Frequency domain parameters. Conclusions: This suggests that Nonlinear (Poincare) parameters specially SD1/SD2 has better sensitivity and specificity as compared to the Linear parameters of HRV in diagnosing CAN in MSA patients.

Where applicable, experiments conform with Society ethical requirements