Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCB148

Poster Communications

Spectrum of esophageal motor abnormalities in patients with scleroderma on high resolution manometry

A. Laabidi1, L. Zouiten1,2, M. Serghini1, J. Boubaker1

1. la Rabta Hospital, Tunis, Dr, Tunisia. 2. Université de Tunis El Manar, Faculté de Médecine de Tunis, Laboratoire de physiologie,, Tunis, Tunisia.

Background/aim: The classic manometric findings in scleroderma esophagus are ineffective peristalsis and reduced esophageal sphincter pressure. With implementation of high-resolution manometry (HRM), different patterns of esophageal dysmotility are seen. The aim of this study is to characterize esophageal motor function by HRM and to assess associations between demographic features and esophagoscopy results and HRM findings. Material and methods: Patients with scleroderma who underwent HRM between January 2017 and May 2018 were identified. Esophageal motility disorders were classified according to the Chicago Classification, v3.0 criteria. Demographic data and esophagoscopy findings were collected via retrospective chart review. Results: A total of 28 patients (96.4% female) with a mean age of 56.5 ± 13 years were included. HRM showed absent contractility (n= 11; 39.3%), ineffective esophageal motility (n=10; 35.7%), esophagogastric junction outflow obstruction (n=1; 3.6%) and normal motility (n=6; 21.4%). Esophagoscopy showed abnormalities more frequently in patients with absent contractility than patients with other motility disorders (80% vs 8.3%, p=0.01). In fact, patients with absent contractility were more likely to have erosive esophagitis than other patients with marginal statistical significance (40% vs 0%, p=0.07). There was no association between age and frequency of erosive esophagitis. However, lower esophageal sphincter pressure was negatively and significantly correlated with age (r=- 0.513; p=0.007). Conclusion: Absent contractility and ineffective esophageal motility are the most common motility disorders in patients with scleroderma. According to endoscopic findings, patients with absent contractility seem to have more severe reflux.

Where applicable, experiments conform with Society ethical requirements