Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCB150

Poster Communications

The Efficiency of Sinapic acid on oxidative parameters in secondary lung and kidney damage in the peritonite model provoked by sepsis in rats

A. Tanyeli1, F. Ekinci Akdemir2, E. Eraslan4, M. C. Guler1, S. Ozbek Sebin1, I. Gulcin3

1. Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey. 2. Department of Nutrition and Dietetics, High School of Health, Agri Ibrahim Cecen University, Agri, Turkey. 3. Department of Biochemistry, Faculty of Science, Ataturk University, Erzurum, Turkey. 4. Department of Physiology, Faculty of Medicine, Bozok University, Yozgat, Turkey.

Sepsis, which requires urgent treatment, is a systemic disease caused by infectional reasons and it leads to shock, organ failure, acute respiratory syndrome and even death. In this study, we examined the possible beneficial effects of Sinapic acid on rat kidney and lung tissue in an experimental cecal ligation puncture model. The cecal ligation was applied to the rats and two through-and-through punctures were made through the antimesenteric face of the cecum and the established CLP polymicrobial sepsis model was performed in the sepsis (CLP) group. 20 mg/kg of Sinapic acid was administered in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were taken and biochemical analyzes were performed. Antioxidant levels decreased, oxidant levels increased in lung and kidney tissues due to CLP. Sinapic acid showed effective results against oxidative stress caused by CLP induction. The results of our study demonstrated that Sinapic acid has beneficial effects on the oxidative stress in the lung and kidney tissues.

Where applicable, experiments conform with Society ethical requirements