Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCB151

Poster Communications

Role of p-Coumaric Acid on Reproductive and Remote Organ Damages Created by Adnexial Torsion/Detorsion

A. Tanyeli1, F. Ekinci Akdemir2, E. Eraslan3, M. C. Guler1, T. Nacar1, I. Gulcin4

1. Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey. 2. Department of Nutrition and Dietetics, High School of Health, Agri Ibrahim Cecen University, Agri, Turkey. 3. Department of Physiology, Faculty of Medicine, Bozok University, Yozgat, Turkey. 4. Department of Biochemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.

The aim of this study is to investigate the possible beneficial effects of p-coumaric acid on ovary and lung injury generated by bilateral ovary torsion/detorsion model in rats. In our study, 24 Sprague-Dawley female rats were randomly divided into 3 groups. Groups planned as group I (sham), group II (T/D) and group III (p-coumaric acid+T/D). In group I, the abdomen was opened and closed again without T/D model. In group II, 3 h of torsion followed 3 h of detorsion were made. In the group III, p-coumaric acid was given orally 100 mg/kg dose for 15 days and T/D was performed as defined in group II. At the end of detorsion period, rats were sacrificed and removed the ovary and lung tissues. MDA level, MPO activity, TOS and OSI values increased significantly in group II according to group I. However, antioxidant enzyme activity and TAS value decreased in group II. Conversely, the antioxidant enzyme activity increased, while OSI value, MPO activity and MDA level decreased significantly due to p-coumaric acid in the group III. As a conclusion, p-coumaric acid was found to be effective in protection on the ovary and lung against damage that formed by experimental T/D in rats.

Where applicable, experiments conform with Society ethical requirements