Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCB208

Poster Communications

Effects of Gum Arabic (Acacia Senegal) on visceral adiposity index and blood pressure in Type 2 Diabetes Mellitus as indicators of cardiovascular disease: a randomized and placebo-controlled clinical study

A. M. Saeed1, R. Babiker2, K. Elmusharaf3, M. Keogh4

1. Physiology, Faculty of medicine/University of Khartoum, Khartoum, Khartoum, Sudan. 2. Physiology, Faculty of Medicine, University of Medical Sciences & Technology, Khartoum, Khartoum, Khartoum, Sudan. 3. Graduate College, Graduate Entry Medical School, University of Limerick,, Limerick, Ireland. 4. Medicine, School of Medicine, Royal College of Surgeons in Ireland RCSI-Bahrain, Manama, Bahrain.

Background: There is a strong association between cardiometabolic risk and adipose tissue dysfunction with great consequences on type 2 diabetic patients. Visceral Adiposity Index (VAI) is an indirect clinical marker of adipose tissue dysfunction. Gum Arabic (GA) is a safe dietary fiber resultant of exudates from Acacia Senegal. GA has shown lipid lowering effect in both humans and animals. Therefore, the aim of this study is to determine the effect of (GA) on anthropometric obesity marker, Visceral Adiposity Index (VAI) and blood pressure in patients with Type 2 diabees. Methods: A total of 91 Type 2 diabetic patients, aged 50.09 ± 9.3 with HA1c more than 7% and on hypoglycemic agents were randomly assigned to receive either 30g of GA or 5g pectin as a placebo daily for 3 months. Waist circumference (WC), systolic (SBP) and diastolic (DBP) blood pressure were measured , VAI, body mass index (BMI), waist-hip ratio (WHR), body adiposity index (BAI), lipid accumulation product (LAP) and deep-abdominal-adipose-tissue (DAAT) accumulation were calculated and high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were determined in fasting blood samples at the start and end of the study period.This study was conducted according to the guidelines by the Declaration of Helsinki and procedures were approved by the Research Ethics Committee - Khartoum State Ministry of Health and the Institutional Review Board at University of Medical Science and Technology (UMST); SUM 116-IRB number: 00008867. The trial is registered under PACTR201403000785219. Results: After intervention, BMI and VAI were decreased in GA group significantly (P < 0.05). BAI and LAP significantly decreased in GA group while no significant difference in WHR or DAAT. Systolic blood pressure significantly decreased (P<0.05) in the GA group and placebo group with no difference in diastolic blood pressure in both groups. Conclusion: Gum Arabic at a dose of 30g /d for 3 months may play an effective role in preventing weight gain and modulating adipose tissue dysfunction in type 2 diabetic patients.

Where applicable, experiments conform with Society ethical requirements