Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCB216

Poster Communications

Dose-Dependent Hemorheological Impairment in Patients with Differentiated Thyroid Cancer Following I-131 Ablation / Metastasis Treatment

T. Sengoz1, E. Kilic-Toprak2, O. Yaylali1, O. Kilic-Erkek2, Y. Ozdemir2, B. Oymak2, H. Senol3, D. Yuksel1, V. Kucukatay2, M. Bor-Kucukatay2

1. Department of Nuclear Medicine, Pamukkale University, Denizli, Turkey. 2. Department of Physiology, Pamukkale University, Denizli, Turkey. 3. Department of Biostatistics, Pamukkale University, Denizli, Turkey.

Therapy of differential thyroid cancer (DTC) is total thyroidectomy followed by radioactive iodine therapy with Iodine-131 (RAIT) (1). Although RAIT is thought to affect blood cells and oxidative stress, hemorheological alterations following dose-dependent RAIT remains unknown. The aim of this study was to determine the effects of three different doses of RAIT on hemorheological parameters in patients with DTC. Serum total oxidant (TOS), total antioxidant (TAS) levels of these patients were also determined in order to explain the reasons of possible rheological alterations. Totally 31 DTC patients (mean age 46.32 ± 11.15 years) and 26 healthy controls (mean age 50.50 ± 6.22 years) were included. Of the 31 patients; 7 (%22.6) were treated with a low (30 mCi) RAIT dose, 19 (%61.3) with ablation (100 mCi) dose and 5 (%16.1) with higher dose (>100 mCi). Venous blood samples were collected from each patient before and after treatment (7 days, 1 month and 6 months). RBC aggregation and deformability were determined by an ektacytometer. TOS and TAS were measured by a commercial kit and the oxidative stress index (OSI) was calculated. Data were analyzed with the SPSS 21.0 program. Analysis of variance in repeated measures was used when parametric test assumptions were provided; and the Friedman test was used when parametric test assumptions were not provided. p <0.05 was considered as statistically significant. RBC deformability of the patients determined at 16.87 and 30 Pascal (Pa) were lower than healthy individuals. RBC aggregation index (AI) of the patients was higher, whereas erythrocyte aggregation half-time (t ½) was lower compared to control (p<0.05). These alterations indicate increased RBC aggregation in patients. Administration of higher dose of RAIT resulted in a further decrease in RBC deformability at 16.87 and 30 Pa 1 week after treatment compared to lower and ablation dose administrations (Table 1). TOS of ablation dose group measured on the first week following treatment was higher than low dose group (p<0.05) (Table 1). Patients were in a worse hemorheological condition compared to healthy individuals. The issue that high dose of RAIT results in further decrement in RBC deformability should be kept in mind especially for patients who are not hemodynamically stable.

Where applicable, experiments conform with Society ethical requirements