Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PCB231

Poster Communications

THE EFFECTS OF PAROXETINE, BUPROPION AND AGOMELATINE ADMINISTRATION ON SEMINAL VESICLE FLUID IN MALE RATS

S. Canpolat1, Z. Sahin2, O. Bulmus3, I. Serhatlioglu4, F. Gulcu Bulmus5, H. Kelestimur1

1. Physiology, Firat University, Medical School, Elazig, Turkey. 2. Physiology, Karadeniz Technical University, Medical School, Trabzon, Turkey. 3. Physical Threapy and Rehabilitation, Firat University, Faculty of Health Sciences, Elazig, Turkey. 4. Biophysics, Firat University, Medical School, Elazig, Turkey. 5. Vocational School of Health Services, Firat University, Elazig, Turkey.


Introduction and Objective: Antidepressants are commonly used drugs in the treatment of psychiatric disorders. There are limited studies on the effects of paroxetine, bupropion and agomelatine on the reproductive system in male rats. It has also been noted that sperm parameters are adversely affected in selective serotonin reuptake inhibitor (SSRI) treatments as a significant side effect of these drugs. It is known that seminal vesicle fluid contains abundant amounts of fructose, citric acid, nutrients, prostaglandins and fibrinogen. Fructose and other nutrients provide nutrition and motility of the sperm in the ejaculate for a period of time until the fertilization of the ovum. The aim of this study is to investigate the possible effects of these antidepressants on the levels of certain components of the seminal vesicle fluid. Methods: In the study, a total of 32 male rats were used and divided into 4 groups. The rats were given oral paroxetine (0.36 mg/100 g), bupropion (17 mg/100 g) and agomelatine (1 mg/100 g) from postnatal day 21 to 90; and only saline was administered to the control group. At the end of the experimental period, the animals were decapitated under anesthesia, seminal vesicle fluids were taken and evaluated. Results: Seminal vesicle fluid fructose levels were significantly decreased in paroxetine (74.9±3 mg/dL) and bupropion (29.3±5 mg/dL) groups (p<0.01); whereas there was no significant difference in the agomelatine group (120.8±12 mg/dL) compared to the control group (169.5±11 mg/dL). Vitamin A levels were significantly increased in bupropion (0.031±0.003 mg/dL) and agomelatine (0.031±0.002 mg/dL) groups, compared to the control group (0.020±0.001 mg/dl) (p<0.05). Vitamin E levels were significantly higher in the agomelatine group (0.152±0.013 mg/dL) than the other groups (p<0.05). Vitamin D levels did not differ between groups. There were no significant differences in seminal vesicle fluid Na, K and Cl levels between groups. Conclusion: Decrease of fructose levels in the seminal fluid due to paroxetine and bupropion may result in decreased vitality and motility of the spermatozoa. This result suggests that reduction in sperm fertilizing ability can be seen in long-term antidepressant use. However, agomelatine may be considered as a more preferable antidepressant with no effect on fructose levels and positive effects on Vit A and Vit E levels. Key Words: Seminal Vesicle, Fructose, Antidepressant, Vitamin.

Where applicable, experiments conform with Society ethical requirements