Proceedings of The Physiological Society

Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, PL007

Prize Lectures

Leucine rich repeat kinase 2: From pathology to physiology and back again

P. A. Lewis1,2

1. School of Pharmacy, University of Reading, Reading, United Kingdom. 2. Institute of Neurology, University College London, London, United Kingdom.


Coding mutations in the LRRK2 gene on chromosome 12 are the most common genetic cause of Parkinson's disease, and have been the subject of intense experimental scrutiny since their identification in 2004. Despite these efforts, we are only just beginning to understand how these mutations lead to cell death in the substantia nigra, with much of this progress deriving from insights into the physiological function and role of LRRK2. In this lecture, the journey from the biochemical and cellular impact of mutations in LRRK2 to a greater understanding of what the normal function of LRRK2 is, and how this has fed back into efforts to dissect the role of LRRK2 in the aetiology of Parkinson's and to targeting this protein in patients, will be described.

Where applicable, experiments conform with Society ethical requirements