Proceedings Abstracts of The Physiological Society

Heart & Cardiac Muscle

Importance of the threonine residue T148 in the pore region for extracellular block and permeation of the cardiac muscarinic K+ channel, Kir3.1-Kir3.4

S.Y. Makary, T.W. Claydon and M.R Boyett

J Physiol 552P (2003)

Agonist-activation of the cardiac muscarinic K+ channel, Kir3.1-Kir3.4, may occur at the selectivity filter

T.W. Claydon, S.Y. Makary, K.M. Dibb and M.R. Boyett

J Physiol 552P (2003)

Preferential closed channel blockade of HERG potassium currents by chemically synthesized BeKm-1 scorpion toxin

James T. Milnes*, Christopher E. Dempsey†, John M. Ridley*, Olivia Crociani‡, Annarosa Arcangeli‡, Jules C. Hancox* and Harry J. Witchel*

J Physiol 552P (2003)

Hyperphosphorylation of slow delayed rectifier potassium channels in mouse hearts expressing KCNQ1-KCNE1 and over-expressing β2-adrenergic receptors

K.W. Dilly*, J. Kurokawa*, S. Reiken†, A. Marks† and R.S. Kass*

J Physiol 552P (2003)

Phenylephrine inhibits an acid-sensitive background K+ current in rat ventricular myocytes

S.C.M. Choisy*, J.C. Hancox*, J.M. Hinton*, L.A. Arberry*, M.J. Shattock† and A.F. James*

J Physiol 552P (2003)

Effects of diazoxide pretreatment on sarcolemmal KATP channel activation and functional protection during metabolic inhibition in rat isolated cardiac myocytes

G.C. Rodrigo, N.W. Davies and N.B. Standen

J Physiol 552P (2003)

Expression of C-terminal fragments of the sulphonylurea receptor SUR2A in rat isolated cardiac myocytes modifies sarcolemmal KATP currents and contractile responses on metabolic inhibition

R.D. Rainbow*, D. Hudman*, N.W. Davies*, D. Lodwick†, R.I. Norman† and N.B. Standen*

J Physiol 552P (2003)

Role of brain type sodium current in murine sino-atrial node pacemaking

S.M. Fung and M. Lei

J Physiol 552P (2003)

β-Adrenergic regulation of cardiac CaV1.2 channels requires anchoring of cAMP-dependent protein kinase via AKAP15 in rat heart

J.T. Hulme, T. Lin, R.E. Westenbroek, T. Scheuer and W.A. Catterall

J Physiol 552P (2003)

Absence of strain-softening in isolated, superfused, passive right-ventricular trabeculae from rat

R.S. Kirton, A. Taberner, A.A. Young, P.M.F. Nielsen and D.S. Loiselle

J Physiol 552P (2003)

Heart rate variability instrumentation: agreement and reliability

G.R.H. Sandercock, C. Shelton and D.A. Brodie

J Physiol 552P (2003)

Decreased heart rate variability in a ferret model of heart failure

Helen K. Graham and A.W. Trafford

J Physiol 552P (2003)

Selective down-regulation of subendocardial ryanodine receptors in a rabbit model of left ventricular dysfunction

S. Currie, R.A. Sayeed* and G.L. Smith

J Physiol 552P (2003)

Sarcoplasmic reticulum calcium fluctuation: the key to systolic calcium transient alternans?

M.E. D

J Physiol 552P (2003)

Force-frequency relation in frog-ventricle

S. Subramani, T. Jyoti, S. Sathish Kumar, S. Balakrishnan, A. Mohammed and C. Vijayanand

J Physiol 552P (2003)

Frequency-dependent changes in sarcoplasmic reticulum Ca2+ content and Ca2+ transients in rat ventricular myocytes under physiological conditions

K.M. Dibb, D.A. Eisner and A.W. Trafford

J Physiol 552P (2003)

Differences in male and female cardiomyocyte function can be related to sarcoplasmic reticulum Ca2+ content and Na+-Ca2+ exchanger activity

R. Liew, M.A. Stagg, P. Collins and K.T. MacLeod

J Physiol 552P (2003)

Inhibition of SR Ca2+ uptake increases Ca2+ efflux generated by propagating waves of Ca2+ release in isolated rat ventricular myocytes

R. Hinch*, D.A. Eisner and S.C. O'Neill

J Physiol 552P (2003)

Effects of calsequestrin over-expression on excitation- contraction coupling in isolated rabbit cardiomyocytes

Stewart LW Miller*, Susan Currie*, Deborah F. Reynolds*, Tim Seidler†, Gerd Hasenfuss† and Godfrey L Smith*

J Physiol 552P (2003)

Detection of low amplitude Ca2+ sparks from confocal line-scan images using permeabilised ventricular cardiomyocytes

C.M. Loughrey*, E.A. Sobie‡, K. MacEachern*, W.J. Lederer‡ and G.L. Smith†

J Physiol 552P (2003)

Modelling of Ca2+ wave characteristics in cardiac muscle over a range of cytoplasmic [Ca2+]

N. Macquaide*, J. Dempster†, C.M. Loughrey* and G.L. Smith*

J Physiol 552P (2003)

Characterization of cystine uptake in rat cardiac sarcolemmal vesicles

Hua Lin, Nicola King, J.D. McGivan*, and M.-Saadeh Suleiman

J Physiol 552P (2003)

Age-dependent decrease of L-type calcium channel protein expression within the sinoatrial node

S.A. Jones, M.K. Lancaster and M.R. Boyett

J Physiol 552P (2003)

Glutamate incubation protects isolated rat cardiomyocytes against oxidative stress

Catherine F. Bryant, Edward C. Coxson, Nicola King and M.-Saadeh Suleiman

J Physiol 552P (2003)

ER retention of mutant KCNQ1 K+ channels expressed in CHO-K1 cells

Andrew J. Wilson*, Fiona M. Graves*, Kathryn V. Quinn, Maria Bitner-Glindzicz† and Andrew Tinker*

J Physiol 552P (2003)

Glutamate loading protects isolated cardiomyocytes against oxidative stress by stimulating glutathione peroxidase

Nicola King, Svetlana Korolchuk and M.-Saadeh Suleiman

J Physiol 552P (2003)

Inhibition by procainamide and N-acetyl procainamide of HERG K+ channels expressed in a mammalian cell line

John M. Ridley, James T. Milnes, Andrew V Benest, Joe D. Masters, Harry J. Witchel and Jules C. Hancox

J Physiol 552P (2003)

Differential responses at 37 °C to insulin of L-type calcium current and cell shortening from guinea-pig isolated ventricular myocytes

Vijay K. Pabbathi, M.-Saadeh Suleiman, Jules C. Hancox

J Physiol 552P (2003)

Sex-related differences in ionic currents of guinea-pig ventricular myocytes

A.F. James, L.A. Arberry and J.C. Hancox

J Physiol 552P (2003)

Arachidonic acid inhibits spontaneous waves of Ca2+ release in rat ventricular isolated myocytes without inhibiting the Ca2+ release mechanism

B. Rashid and S.C. O'Neill

J Physiol 552P (2003)

CellTracker Blue is a good tool for measuring reduced glutathione levels in single isolated and perfused cardiomyocytes?

S. Korolchuk, N. King and M.-S. Suleiman

J Physiol 552P (2003)

The effects of catecholamines on functional recovery and interleukin-6 synthesis in the intact post-ischaemic rat heart

Simon D. Benson, Tom D. Mardling, Nigel Humphreys and M.-Saadeh Suleiman

J Physiol 552P (2003)

The effect of systemic perfusion temperature on cytokine release in paediatric cardiac surgery

Simon Bays, M.-Saadeh Suleiman and Massimo Caputo

J Physiol 552P (2003)

Experimental and computer models of mechanically heterogeneous myocardium

V. Gur'ev and O. Lookin

J Physiol 552P (2003)

Myocyte/fibroblast 2D structured cardiac tissue models

Patrizia Camelliti and Peter Kohl

J Physiol 552P (2003)

Pulse wave analysis of β2-agonist-mediated response in hypertension

Curtis Rambaran, Elizabeth Iveson, Philip J. Chowienczyk, James M. Ritter, Ajay M. Shah, Terrence Forrester and Lalit Kalra

J Physiol 552P (2003)

Diastolic stretch causes transient increase in post-rest contractile activity without concurrent rise in resting [Ca2+]i in isolated guinea-pig ventricular myocytes

Gentaro Iribe, Patricia J. Cooper, Angie M. King and Peter Kohl

J Physiol 552P (2003)

Cytosolic calcium attenuates HERG channel currents expressed in HEK 293 cells via a protein kinase C-dependent pathway

S.L. Cockerill, G.B. Willars, N.B. Standen, J.S. Mitcheson

J Physiol 552P (2003)

Profiling of Ion channel gene expression in mouse heart

J. Liu*, C. Pritchard†, R. Billeter‡, P. Underhill†, M. Lei* and D. Noble*

J Physiol 552P (2003)