Proceedings Abstracts of The Physiological Society

Ion Channels

Role of S6 in activation and inactivation of Kv1.4

Q. Zhou1,2, A. Lis2, H. Guo2, M. Liu2, R. L. Rasmusson2,1, G. C. Bett3,2

Proc Physiol Soc 28 (2012)

Novel mutations in ABCC9 gene: associated with early repolarisation syndrome?

S. Chaigne4, S. Chatel3,1, F. Sacher4, F. Kyndt5,1, G. Loussouarn1,2, H. Le Marec1,3, V. Probst3,1, I. Baró1,2, J. Schott1,2, M. Haïssaguerre4

Proc Physiol Soc 28 (2012)

The TRIC-A knockout mouse model provides insight into the labile gating nature of TRIC-B channels

E. Venturi1, S. J. Pitt1, E. Galfre1, F. O'Brien1, M. Nishi2, H. Takeshima2, R. Sitsapesan1

Proc Physiol Soc 28 (2012)

The molecular and electrophysiological basis of triggered activity arising from the right ventricular outflow tract

H. Schneider1, S. J. Logantha1, M. R. Boyett1, V. S. Mahadevan1, O. Monfredi1, H. Dobrzynski1

Proc Physiol Soc 28 (2012)

Regulation of large conductance voltage- and calcium- activated potassium channels by reversible protein S-acylation

L. Tian1, H. McClafferty1, M. J. Shipston1

Proc Physiol Soc 27 (2012)

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition

S. McKay1, S. Edman1, M. Livesey1, G. E. Hardingham1, D. J. Wyllie1

Proc Physiol Soc 27 (2012)

Heteromeric kainate receptors have a fixed subunit stoichiometry

M. Aurousseau1, P. Brown1,3, H. McGuire2, R. Blunck2, D. Bowie1

Proc Physiol Soc 27 (2012)

Differential effects of hypertension on KCNQ4-encoded voltage dependent potassium channel activity in mesenteric and middle cerebral arteries

P. S. Chadha1, F. Zunke1, C. J. Brookman1, T. A. Jepps1, I. A. Greenwood1

Proc Physiol Soc 27 (2012)

Cl- not K+ controls the plasma membrane potential in rat white adipocytes.

D. C. Bentley1, S. L. Chan1, P. A. Smith1

Proc Physiol Soc 27 (2012)

Orai3 regulates cell proliferation and survival in lung cancer cells

A. Ay1, N. Benzerdjeb1,2, H. Sevestre1,2, A. Ahidouch1,3, H. Ouadid-Ahidouch1

Proc Physiol Soc 27 (2012)

Structure activity relationships of novel BK channel modulators: The GoSlo-SR family

S. Roy2, A. Akande1, R. Large2, T. Webb2, G. P. Sergeant1,2, N. G. McHale1,2, K. D. Thornbury1,2, M. A. Hollywood1,2

Proc Physiol Soc 27 (2012)

The regulation of Ca2+-activated chloride channels by cholesterol and phosphatidylinositol 4,5-bisphosphate in rat pulmonary artery

H. Pritchard1, A. P. Albert1, I. A. Greenwood1

Proc Physiol Soc 27 (2012)

Reactive oxygen species inhibit Slo1 BKCa channels in undifferentiated human mesenchymal stem cells

A. Soloviev1, S. Tishkin1, I. Ivanova1, I. Prudnikov2, V. Tsyvkin2

Proc Physiol Soc 27 (2012)

Functional Ca2+ sensors do not contribute to the effect of the novel BK channel agonist GoSlo-SR5-6

R. Large2, T. I. Webb2, A. Akande1, S. Roy2, G. P. Sergeant1,2, K. D. Thornbury1,2, N. G. McHale1,2, M. A. Hollywood1,2

Proc Physiol Soc 27 (2012)

Aldosterone regulates the TRPM7 chanzyme

W. C. Valinsky1, R. Touyz2,3, A. Shrier1

Proc Physiol Soc 27 (2012)

Multiple actions of TRPM8 agonists in rat tail artery vascular smooth muscle

D. Melanaphy1, C. Watson2, C. D. Johnson2, A. V. Zholos1

Proc Physiol Soc 27 (2012)

Role of acid-sensitive two-pore domain potassium (K2P) channels in cancer progression

S. Williams1, A. Bateman1, I. O'Kelly1

Proc Physiol Soc 27 (2012)

Human Ether

M. Hammadi *1, V. Chopin*1, F. Matifat1, I. Dhennin-Duthille1, M. Chasseraud1, H. Sevestre1,2, H. Ouadid-Ahidouch1

Proc Physiol Soc 27 (2012)

Transient receptor potential melastatin 7 channel is involved in migration of metastatic breast cancer cells through its kinase domain

I. Dhennin-Duthille1, A. Guilbert1, M. Gautier1, P. Rybarczyk1, J. Sahni2, H. Sevestre1,3, A. M. Scharenberg2, H. Ouadid-Ahidouch1

Proc Physiol Soc 27 (2012)

Type 3 IP3 receptors are linked to BK channels via lipid rafts and promote human breast cancer cells proliferation

A. Mound1, S. Bougarn1, H. Ouadid-Ahidouch1, F. Matifat1

Proc Physiol Soc 27 (2012)

The role of cytosolic domains in the trafficking of human Nav1.7

J. Hynes1

Proc Physiol Soc 27 (2012)

Comparative analysis of the molecular mechanisms mediating the Ca2+-, Cd2+- and Zn2+-induced mitochondrial permeability transition

I. Kravenska1, L. Dubitsky2, N. Fedirko2

Proc Physiol Soc 27 (2012)

??4-subunit palmitoylation controls cell surface expression of large conductance calcium- and voltage- dependent potassium (BK) channels

L. Chen1, H. J. McClafferty1, L. Tian1, M. J. Shipston1

Proc Physiol Soc 27 (2012)

Atrioventricular node adaptation to heart failure in a rabbit model

T. Nikolaidou1, A. J. Atkinson1, X. Cai1, J. Yanni1, H. Dobrzynski1, G. Hart1, M. R. Boyett1

Proc Physiol Soc 27 (2012)

Activation of P2X2 receptors in a partially liganded state

O. Stelmashenko1, U. Lalo1, Y. Yang1, V. Compan1, R. North1

Proc Physiol Soc 27 (2012)

Get hot, get blocked - Temperature-dependence of allosteric modulators on nAChRs and GABAARs

I. Rinke1, A. de Faoite1, C. J. Milligan1, C. Haarmann1, A. Brüggemann1, M. George1, N. Fertig1

Proc Physiol Soc 27 (2012)

The flux-coupling region for internal spermine block and its associated gating changes in the Kir2.1 channel

C. Huang1, C. Kuo1,2

Proc Physiol Soc 27 (2012)

Expression and functional studies of the novel CNS protein CACHD1

C. H. Soubrane1, E. B. Stevens2, G. J. Stephens1

Proc Physiol Soc 27 (2012)

Osmosensing in the PVN: A role for TRPV4

C. H. Feetham1, R. Barrett-Jolley1

Proc Physiol Soc 27 (2012)

TASK-1 channel expression and function in oligodendrocytes of the mouse brain: a role in white matter ischemic injury

V. Bay1, A. Lewis1, A. Butt1

Proc Physiol Soc 27 (2012)

Kainate receptor activation involves a sequence of distinct conductance states

G. B. Dawe1, B. A. Daniels2, E. D. Andrews2, D. Bowie2

Proc Physiol Soc 27 (2012)

The role of disulfide bond formation in a non-decaying kainate receptor

B. A. Daniels1, M. P. Aurousseau1, E. D. Andrews1, D. Bowie1

Proc Physiol Soc 27 (2012)

ELIC channel activation in response to agonist concentration jumps

A. Marabelli1, R. Lape1, L. Sivilotti1

Proc Physiol Soc 27 (2012)

The expression & function of potassium channels in mouse N9 microglia

G. Pan1, M. Shipston1

Proc Physiol Soc 27 (2012)

Role of PKC?? in adjusting of extrasynaptic AMPA receptors trafficking in dorsal horn neurons during persistent inflammatory pain

O. Kopach1, V. Viatchenko-Karpinski1, P. Belan1, Y. Tao2, N. Voitenko1

Proc Physiol Soc 27 (2012)

A comparison of neuronal properties in the ventral nucleus of the trapezoid body between two strains of inbred mice.

J. Sinclair1, M. Barnes-Davies2, I. D. Forsythe1

Proc Physiol Soc 27 (2012)

Effects of high concentrations of lidocaine chloride on the recovery of the compound action potential depolarization time

J. Scekic1, M. Drecun1, N. Turkovic2, J. Milic1, V. Jelena1

Proc Physiol Soc 27 (2012)

Effects of lactate on the voltage-gated sodium channels of skeletal muscle: modulating the current opinion

F. Rannou1,2, R. Leschiera2, M. Giroux-Metges1,2, J. Pennec2

Proc Physiol Soc 26 (2012)

Differential effects of cupric ion on TRPC and TRPM2 cation channels

G. Chen1, B. Zeng1, S. Xu1

Proc Physiol Soc 25 (2011)

Impaired vascular Kv7 function in animal models of hypertension

T. A. Jepps1,2, P. S. Chadha1, A. J. Davis1, G. W. Cockerill1, R. S. Hansen2, S. P. Olesen2, I. A. Greenwood1

Proc Physiol Soc 25 (2011)

Vasorelaxant and hypotensive effects of Allium cepa peel hydroalcoholic extract in rat

M. Arabian1, M. Gharib Naseri2, M. Badavi3, A. Ahangarpour4, Z. Hajebrahimi5, M. Firoozi6, M. Arabian7

Proc Physiol Soc 25 (2011)

New insights into the mechanism of ATP sensitivity of cloned smooth muscle ATP-sensitive potassium channels

A. Chadburn1, K. Smith1, P. Tammaro1

Proc Physiol Soc 25 (2011)

Effect of fenamates and their new synthetic analogues on TRPC4 and TRPC5 channels

H. Jiang1, B. Zeng1, G. Chen1, D. Bot1, A. Boa2, S. Xu1

Proc Physiol Soc 25 (2011)

Human erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are up-regulated by Plasmodium falciparum

G. Bouyer1,2, A. Cueff1,2, S. Egee1,2, J. Kmiecik1,2, Y. Maksimova3, E. Glogowska1,2, P. Gallagher3, S. Thomas1,2

Proc Physiol Soc 24 (2011)

New insight into CLC-2 chloride channel function: GlialCAM, a protein defective in a leukodystrophy is a channel subunit in glial cells

E. Jeworutzki1, T. López-Hernández3, X. Gasull2, R. Estévez3,4, M. Pusch1

Proc Physiol Soc 24 (2011)

Phospholipid activation of M-type potassium channels

V. S. Telezhkin1, A. Gibb1, D. A. Brown1

Proc Physiol Soc 23 (2011)

The Pore Structure and Gating Mechanism of K2P Channels

P. Piechotta1, M. Rapedius2, P. J. Stansfeld3, M. K. Bollepalli2, G. Ehrlich1, I. Andres-Enguix4, H. Fritzenschaft2, N. Decher5, M. S. Sansom3,6, S. J. Tucker4,6, T. Baukrowitz2

Proc Physiol Soc 23 (2011)

Nav1.5 deficiency triggered TGF-β1-mediated fibrosis as a key mechanism producing sinus node dysfunction associated with Scn5a disruption and aging in mice

X. Hao1, Y. Zhang2, X. Zhang3, M. Nirmalan1, L. Davies1, D. Konstantinou1, F. Yin1, H. Dobrzynski1, X. Wang4, A. Grace2, H. Zhang3, M. Boyett1, C. L. Huang2, M. Lei1

Proc Physiol Soc 23 (2011)

Mutations of the same conserved glutamate residue in NBD2 of the SUR1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes

R. Mannikko1, S. E. Flanagan2, X. Sim1, D. Segal3, K. Hussain4, S. Ellard2, A. T. Hattersley2, F. M. Ashcroft1

Proc Physiol Soc 23 (2011)

Location of the ATP-dependent gate in the cystic fibrosis transmembrane conductance regulator channel pore

W. Wang1, P. Linsdell1

Proc Physiol Soc 23 (2011)