Proceedings Abstracts of The Physiological Society

Respiratory Physiology

LKB1 expression in carotid body type I cells is required for the ventilatory response of mice to hypoxia but not hypercapnia

A. Mahmoud1, A. Evans1

Proc Physiol Soc 27 (2012)

Placental growth factor knockout mice demonstrate elevated pulmonary hypertension and increased vessel leak

E. Colfer1, C. Costello1, S. De Falco2, P. Mc Loughlin1, K. Howell1

Proc Physiol Soc 27 (2012)

The effect of age on pharyngeal calibre: a mechanism for obstructive sleep apnoea?

T. Carlisle1,2, M. R. Cowie1,2, A. K. Simonds1,2, M. J. Morrell1,2

Proc Physiol Soc 27 (2012)

Effect of Khat (Catha edulis) on bronchial asthma in Jimma University Specialized Hospital, Adult Chest Clinic, Jimma, Ethiopia

E. Y. Teferedegn1, A. Ayana1, A. Yami2,1

Proc Physiol Soc 27 (2012)

Mitochondrial plasticity may determine the development of oxygen-sensitivity in rat carotid body

J. E. Paulet1, R. L. Pye1, H. T. Tran1, H. L. Jordan1, D. R. Ladle1, C. Wyatt1

Proc Physiol Soc 27 (2012)

A modelling approach to assess the contribution of vascular remodelling to increased resistance in hypoxic pulmonary hypertension

S. C. Rowan1, E. Cahill1, K. Howell1, P. McLoughlin1

Proc Physiol Soc 27 (2012)

Identification of lung-selective microRNAs that contribute to the pathophysiology of chronic hypoxic lung disease

N. Ali1, P. McLoughlin1, C. Costello1

Proc Physiol Soc 27 (2012)

Respiratory plasticity following chronic intermittent hypoxia during early neonatal life

R. A. O'Connell1, K. D. O'Halloran2

Proc Physiol Soc 27 (2012)

Endogenous hydrogen sulfide mediates ventilatory response induced by hypoxia

M. Kwiatkoski1,3, R. N. Soriano2,3, E. C. Cárnio2, L. S. Branco3

Proc Physiol Soc 27 (2012)

The novel cyclin-dependent kinase inhibitor, AT7519, overrides neutrophil survival mediated by a major gram positive bacterial cell wall component, lipoteichoic acid

M. A. Tait1, C. D. Lucas1, R. Duffin1, C. Haslett1, A. G. Rossi1

Proc Physiol Soc 27 (2012)

Effect of chronic intermittent hypoxia on reflex recruitment of sternohyoid EMG during airway obstruction in the anaesthetised rat

D. Edge1, J. F. Jones1, A. Bradford2, K. D. O'Halloran3

Proc Physiol Soc 27 (2012)

RhoA pathway is not responsible for the bronchial hyperresponsiveness induced by maternal protein restriction

H. A. Wain1, P. H. Keskivali1, S. A. Davis1, J. W. Holloway1, C. Torrens1

Proc Physiol Soc 27 (2012)

Role of antioxidant vitamin c on hypoxia-induced alteration of VEGF gene expression in diabetic rats

K. K. Das1

Proc Physiol Soc 27 (2012)

Dietary nitrate supplementation reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia

A. Vanhatalo1, J. Fulford2, J. R. Blackwell1, S. J. Bailey1, P. G. Winyard2, A. M. Jones1

Proc Physiol Soc 23 (2011)

Role of Rho-kinase and Src-Family Kinases in carbachol-induced contraction of isolated rat bronchioles.

N. Irechukwu1, G. A. Knock1, J. P. Ward1

Proc Physiol Soc 23 (2011)

Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive lung liquid absorption

W. Wilkinson1, A. Benjamin2, I. De Proost1, M. Orogo-Wenn2, D. Riccardi1, D. Walters2, P. Kemp1

Proc Physiol Soc 23 (2011)

The effect of ageing on the control of breathing: a role for the development of obstructive sleep apnoea.

K. Pugh1, G. Balanos1, S. Taheri1, H. Griffin1

Proc Physiol Soc 23 (2011)

Chronic intermittent hypoxia induces respiratory muscle weakness in neonatal rats which persists into early adult life.

R. A. O'Connell1, K. D. O'Halloran1

Proc Physiol Soc 23 (2011)

Protective effect of hypercapnia on warm ischemia induced free radical damage of lungs retrieved from non-heart-beating donors

D. Hodyc1,2, P. Vaněk1,2, K. Dušková1,2, J. Herget1,2

Proc Physiol Soc 23 (2011)

Overnight changes in neck circumference and pharyngeal calibre in heart failure patients with obstructive sleep apnoea

T. Carlisle1,2, N. Ward1,2, A. Atalla1,2, M. Cowie1,2, A. Simonds1,2, M. Morrell1,2

Proc Physiol Soc 23 (2011)

The asthma associated cytokines IL-13 and TGFβ synergistically increase expression of TRPC6 in human airway smooth muscle

Y. Shaifta1, C. Ribeiro1, C. Karner1, J. P. Ward1

Proc Physiol Soc 23 (2011)

The long acting beta agonist formoterol and the cAMP raising agent forskolin both cause reduced expression of SERCA2 in human airway smooth muscle cells

O. O. Ojo1,2, D. B. Wright1,2, T. H. Lee1,2, J. P. Ward1

Proc Physiol Soc 23 (2011)

Sildenafil alleviates bronchopulmonary dyplasia by up-regulating Hypoxia inducible factor-1α

H. Park1, J. Park2,4, C. Choi3, H. Lee3, B. Kim3, Y. Chun1,4

Proc Physiol Soc 23 (2011)

Intermittent hypoxia/reoxygenation increases respiratory muscle fatigability in neonatal rats: No role for Reactive Oxygen Species

R. A. O'Connell1, K. D. O'Halloran1

Proc Physiol Soc 19 (2010)

Acute Hemispheric Stroke Patients Have Reduced Functional Residual Capacity and Cough Flow Rates

P. Rao1, K. Ward1, C. Reilly1, G. Rafferty1, J. Moxham1

Proc Physiol Soc 19 (2010)

Vascular signalling in the fetal lung is regulated by the FGF-10/FGFR2b/Spry2 airway branching periodicity clock.

C. L. Scott1, D. Walker1, E. Cwiklinski1, A. R. Tee2, S. C. Land1

Proc Physiol Soc 19 (2010)

Differential modulation of respiration in response to percutaneous electrical stimulation delivered during inspiration in man

A. Riza-Khan1, D. A. Green1

Proc Physiol Soc 19 (2010)

Lipoxin expression in horses with recurrent airway obstruction

C. Beynon1

Proc Physiol Soc 19 (2010)

Chronic intermittent hypoxia induces respiratory muscle dysfunction in neonatal rats.

R. A. O'Connell1, K. D. O'Halloran1

Proc Physiol Soc 19 (2010)

Chronic hypoxia increases rat diaphragm muscle endurance and Na+-K+ ATPase pump content

C. McMorrow1, A. Fredsted2, J. Carberry1, R. O'Connell1, A. Bradford3, J. Jones1, K. O'Halloran1

Proc Physiol Soc 19 (2010)

Effects of chronic intermittent hypoxia on rat sternohyoid muscle structure and function

C. Shortt1, K. D. O'Halloran1

Proc Physiol Soc 19 (2010)

Chronic intermittent hypoxia does not affect upper airway dilator muscle function in aged male rats

R. Skelly1, A. Bradford2, K. O'Halloran1

Proc Physiol Soc 19 (2010)

Reduced synaptic inhibition underlies respiratory apneas in a mouse model of Rett syndrome (RTT).

A. P. Abdala2, M. Dutschmann3, J. M. Bissonnette1, J. F. Paton2

Proc Physiol Soc 15 (2009)

Knockdown of SERCA-2 in human airway smooth muscle from healthy subjects recapitulates a phenotype associated with asthma

O. O. Ojo1, K. Mahn1, M. R. Holt3, S. J. Hirst2, T. H. Lee1, J. P. Ward3

Proc Physiol Soc 15 (2009)

Chemosensitive astrocytes in the rostral ventrolateral medulla

N. Marina1, V. Kasimov1, M. Figuereido2, S. Kasparov2, A. Gourine1

Proc Physiol Soc 15 (2009)

Mechanisms of H2S-induced contraction of rat pulmonary artery

M. Connolly1, F. Akter1, J. P. Ward1, P. I. Aaronson1

Proc Physiol Soc 15 (2009)

Mechanisms underlying cyclic GMP-mediated Ca2+ desensitisation in rat intrapulmonary arteries

S. Drndarski1, A. De Silva1, G. A. Knock1, P. I. Aaronson1, J. P. Ward1

Proc Physiol Soc 15 (2009)

Relationship Between Glutathione Redox State And The Vasoconstrictor Response To Hypoxia In Rat Pulmonary Arteries

J. Prieto-Lloret1, J. P. Ward1, P. I. Aaronson1

Proc Physiol Soc 15 (2009)

Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress.

C. Costello1, K. Howell1, S. Doherty2, F. Martin3, J. Belperio4, M. Keane1, S. Gaine2, P. McLoughlin1

Proc Physiol Soc 15 (2009)

Intermittent Hypoxia Impairs Rat Upper Airway Muscle Function: Protective Effects of a Superoxide Scavenger

S. Coyle-Rowan1, K. D. O'Halloran1

Proc Physiol Soc 15 (2009)

Effects of Hypoxia on Geniohyoid Muscle Force and Endurance in Young Lean and Old Obese Male Rats

E. Lucking1, K. D. O'Halloran1

Proc Physiol Soc 15 (2009)

VEGF family members can inhibit angiogenesis in the hypoxic lung.

M. Sands1, K. Howell1, C. Costello1, P. McLoughlin1

Proc Physiol Soc 15 (2009)

Oxidant/antioxidant status in hypoxic rats after submission to deep hypothermia

T. Carbonell1, N. Alva1, J. Palomeque1

Proc Physiol Soc 15 (2009)

The superoxide scavenger Tempol improves pharyngeal dilator muscle function in old obese male rats

J. R. Skelly1, K. D. O'Halloran1

Proc Physiol Soc 15 (2009)

Respiratory muscle plasticity following chronic intermittent hypoxia in male but not female Wistar rats.

J. R. Skelly1, A. Bradford2, K. D. O'Halloran1

Proc Physiol Soc 15 (2009)

Illness, body mass index and leptin

A. Taylor1, R. Baskerville2, L. M. Castell1

Proc Physiol Soc 12 (2008)

The role of peripheral and central chemoreceptors in the hypermetabolism-induced increases in the ventilatory chemosensitivity to CO2 in humans

C. Lykidis1, P. Kumar2, G. Balanos1

Proc Physiol Soc 12 (2008)

Hypoxia-induced impairment in rat respiratory muscles during development

J. Carberry1, A. Bradford2, K. D. O'Halloran1

Proc Physiol Soc 11 (2008)

Unilateral ablation of neurokinin-1 receptor-expressing (NK1R) neurones within the pre-Bötzinger complex (preBötC) in adult rats disrupts breathing during sleep but not during wakefulness

Leanne Campbell McKay1, Jack L Feldman1

Proc Physiol Soc 3 (2006)

Brainstem PCO2 modulates phrenic responses resulting from specific carotid body oxygen in an in situ dual-perfused rodent preparation

Trevor A Day1, Richard JA Wilson1

Proc Physiol Soc 3 (2006)