Proceedings Abstracts of The Physiological Society

Smooth Muscle

Role of TRPA1 and TRPM8 channels in intrinsic vascular responses to cold

L. Alonso2,1, K. Talavera2, M. Perez-Garcia1, J. Lopez-Lopez1

Proc Physiol Soc 41 (2018)

Smooth muscle cell iron homeostasis is autonomously controlled by the hepcidin/ferroportin axis and its disruption leads to pulmonary arterial hypertension

S. Lakhal-Littleton1, A. Crosby2, G. Mohammad1, B. Davies1, P. A. Robbins1

Proc Physiol Soc 41 (2018)

The muscarinic receptor modulator gallamine induces proliferation of airway smooth muscle cells.

R. STAMATIOU1, E. Paraskeva1, A. Vasilaki1, A. Hatziefthimiou1

Proc Physiol Soc 41 (2018)

NFAT5/TonEBP - a mechanoresponsive transcription factor that controls arterial remodeling

M. Zappe1, A. Feldner1, C. Arnold1, D. Komljenovic2, C. Sticht1, C. De La Torre1, M. Hecker1, W. Neuhofer1, T. Korff1

Proc Physiol Soc 41 (2018)

Renal resistance arteries are sensitized to L-type Ca2+ channel activation in response to renal denervation

S. Pfannkuch1, J. Witte1, R. Rettig1, R. Schubert2, O. Grisk1

Proc Physiol Soc 41 (2018)

How Does Extracellular Acidification Increase Mouse Uterine Contractions?
How much do we know?

A. M. Almohanna1,2, S. Wray1

Proc Physiol Soc 41 (2018)

Organotypic expression of vascular smooth muscle Kv7.1 channels - potential for renoprotection?

R. Schubert1, A. Bachmann1, F. Stocker1, P. Quinn1, S. Braun1, C. Kammermeier2, A. Kannt2, N. Schmidt1

Proc Physiol Soc 41 (2018)

Organization of vascular smooth muscle cells as multilayered organoids triggers their resting state

M. Jäger1, A. Feldner1, M. Hecker1, C. Arnold1, T. Korff1

Proc Physiol Soc 41 (2018)

The Epidermal growth factor receptor mediates cardiac hypertrophy and structural associated gene expression alteration in the aorta of diabetes mellitus type II mice.

C. Stern1, B. Schreier1, S. Rabe1, S. Mildenberger1, M. Gekle1

Proc Physiol Soc 41 (2018)

The Gq protein inhibitor FR900359 induces strong vasodilation in pulmonary arteries

A. Seidinger1, G. König2, E. Kostenis2, B. K. Fleischmann1, D. Wenzel1

Proc Physiol Soc 41 (2018)

Platelet derived growth factor driven vascular smooth muscle cell remodelling potentiates abdominal aortic aneurysm

P. Kandavelu1, K. E. Porter1, D. J. Beech1, M. A. Bailey1

Proc Physiol Soc 41 (2018)

Inverse relationship between the media-to-lumen ratio and smooth muscle contractile function in resistance arteries from patients with residual cardiovascular disease

M. Bloksgaard1, S. Möller2, T. Leurgans1, A. Irmukhamedov3, L. P. Riber3, Y. Wang4, J. G. De Mey1,3

Proc Physiol Soc 41 (2018)

Disruption of the smooth muscle actin cytoskeleton decreases human resistance artery stiffness and abolishes smooth muscle contractile function

M. Bloksgaard1, M. Morales-Quinones2, L. Martinez-Lemus2

Proc Physiol Soc 41 (2018)

Influence of muscle mass on capillarity and fibre composition in fast muscles of inbred and wild type rats

M. H. Nazir1, S. Egginton1

Proc Physiol Soc 41 (2018)

The assembly of a mass spectrometry-based library of the guinea pig proteome as a tool for physiology research

P. Palmowski1, R. Watson1, N. Europe-finner1, A. Treumann2, M. Taggart1

Proc Physiol Soc 40 (2018)

The effect of visfatin on myometrial contractility

S. Alsaif1, S. Wray1

Proc Physiol Soc 39 (2017)

Strategical positioning of chromatin anchoring NET protein complexes in the nuclear invaginations of pulmonary arterial smooth muscle cells

J. Duan1, J. Navarro-Dorado1, A. M. Evans1

Proc Physiol Soc 37 (2016)

Repeated intravesical gemcitabine increases voiding frequency, compliance and urothelial release of ATP and PGE2 in the murine bladder

C. McDermott1, S. Farr1, R. Chess-Williams1

Proc Physiol Soc 37 (2016)

Muscarinic receptor-induced contractions of the detrusor are mediated by activation of TRPC4 channels

C. Griffin1, M. Hollywood1, K. D. Thornbury1, N. G. McHale1, G. P. Sergeant1

Proc Physiol Soc 37 (2016)

Differential enhancement of phenylephrine and histamine contractions of rabbit carotid arteries following Na+-K+ATPase inhibition

O. O. Arishe1,3, O. K. Uche1,3, A. B. Ebeigbe1,2

Proc Physiol Soc 37 (2016)

The effect of dual combination of Magnesium sulphate with atosiban and indomethacin on myometrial contractions of pregnant mouse

B. Osaghae1, S. Arrowsmith1, S. Wray1

Proc Physiol Soc 37 (2016)

The contribution of Ca2+-activated chloride channels to corpus cavernosum activity

K. Hannigan1, G. P. Sergeant1, M. Hollywood1, K. D. Thornbury1

Proc Physiol Soc 37 (2016)

Investigation into the bimodal effects of Niflumic acid and Anthracene-9-Carboxylic acid on TMEM16A currents expressed in Human Embryo Kidney cells

S. J. Fedigan1, T. Webb1, M. Hollywood1, N. G. McHale1, K. D. Thornbury1, G. P. Sergeant1

Proc Physiol Soc 37 (2016)

Human monocytes adhere to vascular smooth muscle cells in a proinflammatory environment

S. M. Drysdale1, G. A. Gibson2, H. M. Wilson1, G. F. Nixon1

Proc Physiol Soc 37 (2016)

An investigation into the effects of extracellular acidification on mouse uterine contractions

A. M. Almohanna1, K. Noble1, S. Wray1

Proc Physiol Soc 37 (2016)

AMPK-activated protein kinase α1 controls cytosolic calcium concentration and induces calcium sensitization in resistance arteries

T. Metzinger1,2, C. Dufeys2, C. Dessy1, S. Horman2

Proc Physiol Soc 37 (2016)

KV7 channel activators inhibit pregnant mouse myometrium uterine contractility and delay RU486 induced preterm birth

Y. T. Mansour1, R. Patel1, I. A. Greenwood2, S. K. England3, P. Taylor1, R. M. Tribe1

Proc Physiol Soc 37 (2016)

Activation of calcium/calmodulin-dependent kinase 2 (CaMKII) mediates Epac-induced increases in spontaneous transient outward current in rat mesenteric artery smooth muscle

E. S. Humphries1, T. Kamishima2, J. M. Quayle2, C. Dart1

Proc Physiol Soc 37 (2016)

Action of somatostatin and analogues on human lymphatic vessels

F. T. Skov1, V. E. Hjortdal2, D. B. Bødtkjer1

Proc Physiol Soc 37 (2016)

The altered gene expressions induced by the lysine deacetylase (KDAC) inhibitor trichostatin A in HAP1 cells is unaffected by knockout of KDAC8 or KDAC1

I. A. Ghouri1, N. Ossai2, G. N. Europe-Finner1, M. Taggart1

Proc Physiol Soc 37 (2016)

The calcium-sensing receptor in vascular smooth muscle and endothelial cells elicits opposing effects on vascular tone

M. Schepelmann1,2, P. Yarova1, I. Lopez-Fernandez1,3, S. C. Brennan1, T. Davies1, A. Aggarwal4, A. Herberger5, J. Hwong5, W. Chang5, V. Matchkov6, D. Ward7, R. Mentaverri3, D. Edwards8, P. J. Kemp1, D. Riccardi1

Proc Physiol Soc 34 (2015)

A computational model of the ionic currents and action potentials underlying contraction of isolated urinary bladder smooth muscle

C. Mahapatra1, K. Brain2, R. Manchanda1

Proc Physiol Soc 34 (2015)

Differential Kv7 subunit interaction in vascular smooth muscle cells of mesenteric and renal arteries in the normotensive and spontaneously hypertensive rat

H. Spiers1, G. Carr1, I. A. Greenwood1

Proc Physiol Soc 34 (2015)

Similarity and differences in action of high-energy photon and proton irradiation on vascular function in rats

A. I. Soloviev1, T. Novokhatska1, K. Klymenko1, I. Monchak1, A. Khromov1, N. Dobrelya1, O. Pavlova1, A. Valkov2, A. Piskarev2, P. Nolan3, P. Pusa3, A. Nahum4

Proc Physiol Soc 34 (2015)

Examining the effects of vitamin D receptor activators (VDRAs) on vascular smooth muscle cell (VSMC) calcification using intact vessels from chronic kidney disease (CKD) patients

J. L. Laycock1, B. Caplin2, R. Fish2, B. Lindsey2, D. Wheeler2, D. Long1, C. Shanahan3, R. Shroff4

Proc Physiol Soc 34 (2015)

The use of inert bulking agents to reduce pig bladder spontaneous contraction

D. G. Kitney1,2, R. Jabr1, C. H. Fry2

Proc Physiol Soc 34 (2015)

Evidence of a role for TRPV2 channels in retinal arteriolar myogenic signalling

M. K. McGahon1, J. A. Fernandez1, J. D. McKee1, D. P. Dash1, A. V. Zholos2, G. J. McGeown1, T. M. Curtis1

Proc Physiol Soc 34 (2015)

Pulse waveform analysis reveals vascular contributions to Gordon Syndrome and Gitelman Syndrome blood pressure homeostasis

K. Siew1, J. Zhang2, F. Schumacher2, D. R. Alessi2, T. Kurtz2, K. M. O'Shaughnessy1

Proc Physiol Soc 34 (2015)

In vitro effects of ivabradin hydrochloride on carbachol-induced contractions of rat detrussor muscle

H. R. Aydin1, H. Turgut2, A. KURT3, R. Sahan3, A. AYAR3

Proc Physiol Soc 34 (2015)

Spreading of micromotions in juvenile rat bladder: directionality and function of gap junctions

D. A. Bijos1, M. J. Drake1,2

Proc Physiol Soc 34 (2015)

Characterisation of the chemerin signalling pathway: CCX832 is a selective antagonist for the human CMKLR1 receptor

A. Kennedy1, R. Kuc1, J. Maguire1, A. Davenport1

Proc Physiol Soc 34 (2015)

Age-associated alterations in mitochondrial architecture and motility in vascular smooth muscle

S. Chalmers1, C. Saunter2, J. M. Girkin2, J. G. McCarron1

Proc Physiol Soc 33 (2015)

Flicker-assisted localisation microscopy reveals altered mitochondrial architecture in vascular smooth muscle in hypertension

S. Chalmers1, C. Saunter2, J. M. Girkin2, J. G. McCarron1

Proc Physiol Soc 31 (2014)

Evaluation of small molecule inhibitors of nuclear factor kappa B (NF+

L. R. Gurney1, J. Taggart1, S. Robson1, M. Taggart1

Proc Physiol Soc 31 (2014)

Further investigation into the role of Kv7 channels in +

K. S. Jahan1, J. B. Stott1, I. A. Greenwood1

Proc Physiol Soc 31 (2014)

Investigation of Kv7 (KCNQ) modulators on contractility of normal and overactive rat bladder

L. Baysting1, K. D. McCloskey1

Proc Physiol Soc 31 (2014)

Bone Morphogenetic Protein 4 (BMP4) Inhibits Platelet-Derived Growth Factor (PDGF)-Induced Collagen Synthesis in Pulmonary Artery Smooth Muscle Cells (PASMCs)

W. Han1, Y. Su1

Proc Physiol Soc 31 (2014)

Contractile desensitisation to UTP is enhanced in spontaneously-hypertensive rats only after hypertension is established

C. A. Nash2, R. Jackson1, R. Challiss2, J. M. Willets3, R. D. Rainbow1

Proc Physiol Soc 31 (2014)

Potassium channels contribute to vasorelaxant activities induced by Tridax procumbens aqueous leave extract in rat mesenteric artery

H. M. Salahdeen2,1, A. A. Alada1,2, B. A. Murtala1,2, A. O. Adebari2,1

Proc Physiol Soc 31 (2014)

Human mesenchimal stem cells transplant failed to restore vasodilator potential in vascular tissues from diabetic rats but succeeded in spontaneously hypertensive rats

A. I. Soloviev1, I. Ivanova2, T. Novokhatska3, K. Klymenko4

Proc Physiol Soc 31 (2014)