Proceedings Abstracts of The Physiological Society

Smooth Muscle

The calcium-sensing receptor in vascular smooth muscle and endothelial cells elicits opposing effects on vascular tone

M. Schepelmann1,2, P. Yarova1, I. Lopez-Fernandez1,3, S. C. Brennan1, T. Davies1, A. Aggarwal4, A. Herberger5, J. Hwong5, W. Chang5, V. Matchkov6, D. Ward7, R. Mentaverri3, D. Edwards8, P. J. Kemp1, D. Riccardi1

Proc Physiol Soc 34 (2015)

A computational model of the ionic currents and action potentials underlying contraction of isolated urinary bladder smooth muscle

C. Mahapatra1, K. Brain2, R. Manchanda1

Proc Physiol Soc 34 (2015)

Differential Kv7 subunit interaction in vascular smooth muscle cells of mesenteric and renal arteries in the normotensive and spontaneously hypertensive rat

H. Spiers1, G. Carr1, I. A. Greenwood1

Proc Physiol Soc 34 (2015)

Similarity and differences in action of high-energy photon and proton irradiation on vascular function in rats

A. I. Soloviev1, T. Novokhatska1, K. Klymenko1, I. Monchak1, A. Khromov1, N. Dobrelya1, O. Pavlova1, A. Valkov2, A. Piskarev2, P. Nolan3, P. Pusa3, A. Nahum4

Proc Physiol Soc 34 (2015)

Examining the effects of vitamin D receptor activators (VDRAs) on vascular smooth muscle cell (VSMC) calcification using intact vessels from chronic kidney disease (CKD) patients

J. L. Laycock1, B. Caplin2, R. Fish2, B. Lindsey2, D. Wheeler2, D. Long1, C. Shanahan3, R. Shroff4

Proc Physiol Soc 34 (2015)

The use of inert bulking agents to reduce pig bladder spontaneous contraction

D. G. Kitney1,2, R. Jabr1, C. H. Fry2

Proc Physiol Soc 34 (2015)

Evidence of a role for TRPV2 channels in retinal arteriolar myogenic signalling

M. K. McGahon1, J. A. Fernandez1, J. D. McKee1, D. P. Dash1, A. V. Zholos2, G. J. McGeown1, T. M. Curtis1

Proc Physiol Soc 34 (2015)

Pulse waveform analysis reveals vascular contributions to Gordon Syndrome and Gitelman Syndrome blood pressure homeostasis

K. Siew1, J. Zhang2, F. Schumacher2, D. R. Alessi2, T. Kurtz2, K. M. O'Shaughnessy1

Proc Physiol Soc 34 (2015)

In vitro effects of ivabradin hydrochloride on carbachol-induced contractions of rat detrussor muscle

H. R. Aydin1, H. Turgut2, A. KURT3, R. Sahan3, A. AYAR3

Proc Physiol Soc 34 (2015)

Spreading of micromotions in juvenile rat bladder: directionality and function of gap junctions

D. A. Bijos1, M. J. Drake1,2

Proc Physiol Soc 34 (2015)

Characterisation of the chemerin signalling pathway: CCX832 is a selective antagonist for the human CMKLR1 receptor

A. Kennedy1, R. Kuc1, J. Maguire1, A. Davenport1

Proc Physiol Soc 34 (2015)

Age-associated alterations in mitochondrial architecture and motility in vascular smooth muscle

S. Chalmers1, C. Saunter2, J. M. Girkin2, J. G. McCarron1

Proc Physiol Soc 33 (2015)

Flicker-assisted localisation microscopy reveals altered mitochondrial architecture in vascular smooth muscle in hypertension

S. Chalmers1, C. Saunter2, J. M. Girkin2, J. G. McCarron1

Proc Physiol Soc 31 (2014)

Evaluation of small molecule inhibitors of nuclear factor kappa B (NF+

L. R. Gurney1, J. Taggart1, S. Robson1, M. Taggart1

Proc Physiol Soc 31 (2014)

Further investigation into the role of Kv7 channels in +

K. S. Jahan1, J. B. Stott1, I. A. Greenwood1

Proc Physiol Soc 31 (2014)

Investigation of Kv7 (KCNQ) modulators on contractility of normal and overactive rat bladder

L. Baysting1, K. D. McCloskey1

Proc Physiol Soc 31 (2014)

Bone Morphogenetic Protein 4 (BMP4) Inhibits Platelet-Derived Growth Factor (PDGF)-Induced Collagen Synthesis in Pulmonary Artery Smooth Muscle Cells (PASMCs)

W. Han1, Y. Su1

Proc Physiol Soc 31 (2014)

Contractile desensitisation to UTP is enhanced in spontaneously-hypertensive rats only after hypertension is established

C. A. Nash2, R. Jackson1, R. Challiss2, J. M. Willets3, R. D. Rainbow1

Proc Physiol Soc 31 (2014)

Potassium channels contribute to vasorelaxant activities induced by Tridax procumbens aqueous leave extract in rat mesenteric artery

H. M. Salahdeen2,1, A. A. Alada1,2, B. A. Murtala1,2, A. O. Adebari2,1

Proc Physiol Soc 31 (2014)

Human mesenchimal stem cells transplant failed to restore vasodilator potential in vascular tissues from diabetic rats but succeeded in spontaneously hypertensive rats

A. I. Soloviev1, I. Ivanova2, T. Novokhatska3, K. Klymenko4

Proc Physiol Soc 31 (2014)

Altered expression of phosphoprotein enriched in astrocytes-15 in murine and human models of neointima hyperplasia

F. H. Greig1, S. Kennedy2, G. Gibson3, G. F. Nixon1

Proc Physiol Soc 31 (2014)

The role of Ca2+-activated Cl- channels in vascular smooth muscle cells

V. S. Dam1, C. Aalkjaer1, V. V. Matchkov1

Proc Physiol Soc 31 (2014)

Analysis Of Calmodulin Dependent Kinase II (CaMKII)-delta and -gamma subunit expression between three different human smooth muscle tissues

J. Lartey1, J. Taggart1, S. C. Robson1, M. J. Taggart1

Proc Physiol Soc 31 (2014)

Bioinformatic and experimental validation of 3' exon alternative splicing of Myosin Phosphatase Targeting (MYPT) subunits in human muscles

J. Lartey1, K. North1, J. Taggart1, S. C. Robson1, M. Taggart1

Proc Physiol Soc 31 (2014)

Direct visualisation of smooth muscle cell phenotypic plasticity and migration by long-term imaging

M. E. Sandison1, S. Chalmers1, J. Dempster1, J. G. McCarron1

Proc Physiol Soc 31 (2014)

Inhibition of human vascular smooth muscle cell migration occurs via exchange protein activated by cAMP (Epac)

J. S. McKean1, S. J. Tucker1, G. Gibson2, D. A. Shewan1, G. F. Nixon1

Proc Physiol Soc 31 (2014)

The effects of heating from 37-50oC on bladder spontaneous contractions

D. G. Kitney1, B. Vahabi2, R. I. Jabr1, C. H. Fry1

Proc Physiol Soc 31 (2014)

Resolvins do not relax isolated rat thoracic aorta

M. Jannaway1, A. P. Sampson1, J. A. Warner1, C. Torrens2

Proc Physiol Soc 31 (2014)

Functional role of CFTR in rat mesenteric artery

H. T. Pritchard1, N. Lee1, G. Carr1, A. P. Albert1, I. A. Greenwood1

Proc Physiol Soc 31 (2014)

Deletion of the ion channel TRPV4 increases detrusor contractility in the mouse

A. C. Ramos-Filho2, F. Johnson1, E. Antunes2, A. Grant1

Proc Physiol Soc 30 (2013)

Decreased TRPV4 activity in female mouse bladder enhances muscarinic contractions

F. Johnson1, A. C. Ramos-Filho2, A. Shah1, E. Antunes2, A. Grant1

Proc Physiol Soc 30 (2013)

Endothelial SHIP2 confers age-dependent contrasting affects on whole body glucose homeostasis and vascular function

M. Gage1, S. Wheatcroft1, A. Abbas1, H. Imrie1, H. Viswambharan1, S. Galloway1, P. Sukumar1, R. Cubbon1, J. Smith1, S. Schurmans2, M. Jacoby2, E. Dubois2, M. Kearney1

Proc 37th IUPS (2013)

The impact of advanced maternal age on the initiation and progress of parturition in a pregnant mouse model

R. Patel1

Proc 37th IUPS (2013)

Phosphodiesterase-5 activity exerts a coronary vasoconstrictor influence in awake swine that is partly mediated via an increase in endothelin production

Z. Zhou1, V. J. de Beer1, S. B. Bender2, H. Laughlin2, D. Merkus1, D. J. Duncker1

Proc 37th IUPS (2013)

A toxicity profile of the aqueous calyx extract of Hibiscus sabdariffa in Sprague Dawley rats

F. B. Mojiminiyi1

Proc 37th IUPS (2013)

Endothelial relaxation mechanisms dysfunction are reversed by atorvastatin or metformin in animals with estrogen deficiency state

I. F. Caliman1, P. W. Oliveira1, A. Z. Lamas1, S. G. Figueiredo1, P. L. Dalpiaz1, G. J. Sousa1, N. S. Bissoli1

Proc 37th IUPS (2013)

Kv7 channels are major determinants of basal coronary flow and active response to ischemia

S. Khanamiri1, E. Soltysinska1, T. A. Jepps2, B. H. Bentzen1, P. S. Chadha2, N. Schmitt1, I. A. Greenwood2, S. Olesen1

Proc 37th IUPS (2013)

Cardioprotection from cold stress and subsequent fatty diet is mediated by Epac-1 in the isolated mouse heart

F. Edland1

Proc 37th IUPS (2013)

Flow-mediated outward remodeling and NO-dependent dilation of resistance arteries are both determined by sex and age with a key role of timing in estradiol replacement therapy

K. Tarhouni1, A. Guihot1, L. Grimaud1, B. Toutain1, L. Loufrani1, F. Lenfant2, J. Arnal2, D. Henrion1

Proc 37th IUPS (2013)

The effect of l-arginine on microvascular reactivity in normotensive subjects with family history of hypertension

Z. Melik1, P. Zaletel1, T. Virtic1, K. Cankar1

Proc 37th IUPS (2013)

Improvement of blood-retinal barrier breakdown in type 2 diabetic rats by alpha-mangostin

C. Areebambud1, C. Mekseepralard2, A. Jariyapongskul1

Proc 37th IUPS (2013)

Neuropilin-1 regulates endothelial focal adhesion turnover via p130Cas phosphorylation.

I. Evans1, W. Pickworth1, G. Schey1, P. Frankel1, I. C. Zachary1

Proc 37th IUPS (2013)

The role of Na+/H+ exchanger-1 during ischemia-induced cerebrovascular dysfunction

Y. Jung1

Proc 37th IUPS (2013)

Assessment of arterial distensibility in patients with sarcoidosis

H. Balci1, S. Sipahi Demirkok2, M. Yildiz3, G. Metin3, M. Hacibekiroglu1, G. Simsek3

Proc 37th IUPS (2013)

Increased permeability of pulmonary arterioles after cardiopulmonary bypass.

T. Beleznai1, L. Walker2, R. Ascione2, K. A. Dora1

Proc 37th IUPS (2013)

Peripheral circulatory changes during Valsalva maneuver using DC component of Photoplethysmographic signal

D. S. Chandran1, A. J. Kattoor1, A. K. Jaryal1, K. K. Deepak1

Proc 37th IUPS (2013)

Aliskiren associate with L-Arginine improves vascular reactivity of renovascular hypertension rats

C. Santuzzi1, R. V. Tiraddentes1, V. Mengal1, H. Mauad1, P. Matos1, S. A. Gouvea1, M. H. Cunha1, G. R. Abreu1

Proc 37th IUPS (2013)

Pharmacological analysis of sympathetically-mediated constriction in wild type and +

C. Stevenson1, C. Daly1, E. McLachlan2, I. McGrath1

Proc 37th IUPS (2013)

Mathematical modelling of capillary O2 supply capacity in cardiac and skeletal muscle

A. A. Al-Shammari1, E. A. Gaffney1, S. Egginton2,3

Proc 37th IUPS (2013)

The effects of Insulin-like Growth Factor Binding Protein-1 on endothelial repair in the insulin resistant setting

A. Aziz1, N. Yuldasheva1, J. Smith1, N. Haywood1, P. Cordell1, R. Cubbon1, K. E. Porter1, M. T. Kearney1, S. B. Wheatcroft1

Proc 37th IUPS (2013)