Proceedings Abstracts of The Physiological Society

Serum- and glucocorticoid-inducible kinase 1 promotes vascular smooth muscle cell calcification via NF-kB

J. Voelkl1, T. Luong1, R. Tuffaha2, K. Musculus2, T. Auer2, X. Lian3, C. Daniel4, D. Zickler3, B. Boehme1, M. Sacherer5, B. Metzler6, D. Kuhl7, M. Gollasch3, K. Amann4, D. Müller8, B. Pieske1,9,10, F. Lang2, I. Alesutan1,9

Proc Physiol Soc 41 (2018)

Investigation of the effects of tetrahydrobiopterin on renal nitric oxide synthase isoforms in Experimental Myoglobinuric Acute Kidney Injury

N. Aydogdu1, H. Erbas2, E. Tastekin3, N. Kandemir1, M. Aydin1, N. Sut4

Proc Physiol Soc 41 (2018)

Uromodulin inhibits medial vascular calcification by interfering with pro-inflammatory cytokines

I. Alesutan1,2, T. Luong1, N. Schelski1, J. Masyout1, S. Hille3, M. Schneider4, D. Zickler5, N. Verheyen6, M. Estepa1, A. Pasch7, W. Maerz8, A. Tomaschitz9, S. Pilz10, N. Frey3, F. Lang11, O. Mueller3, B. Pieske1,2,12, K. Eckardt5, J. Scherberich13, J. Voelkl1

Proc Physiol Soc 41 (2018)

Genetic deletion of cyclooxygenase-2 impairs glomerular slit diaphragm formation during late stages of kidney development

K. Madsen1, N. Marcussen2, B. L. Jensen1

Proc Physiol Soc 41 (2018)

Plasminogen deficiency attenuates angiotensin II-induced hypertension in diabetic mice

M. H. Hansen1, H. Andersen1, K. Buhl1, M. Stæhr1, U. Friis1, P. Svenningsen1, C. Enggaard1, I. Lund2, S. Supramaniyam1, P. Lærkegaard Hansen1, B. L. Jensen1

Proc Physiol Soc 41 (2018)

Mechanisms involved in relaxations induced by electrical field stimulation in murine airways smooth muscle.

X. Lim1, E. Bradley1, G. Sergeant1, M. Hollywood1, K. D. Thornbury1

Proc Physiol Soc 41 (2018)

The Epidermal growth factor receptor mediates cardiac hypertrophy and structural associated gene expression alteration in the aorta of diabetes mellitus type II mice.

C. Stern1, B. Schreier1, S. Rabe1, S. Mildenberger1, M. Gekle1

Proc Physiol Soc 41 (2018)

The Gq protein inhibitor FR900359 induces strong vasodilation in pulmonary arteries

A. Seidinger1, G. König2, E. Kostenis2, B. K. Fleischmann1, D. Wenzel1

Proc Physiol Soc 41 (2018)

Platelet derived growth factor driven vascular smooth muscle cell remodelling potentiates abdominal aortic aneurysm

P. Kandavelu1, K. E. Porter1, D. J. Beech1, M. A. Bailey1

Proc Physiol Soc 41 (2018)

Inverse relationship between the media-to-lumen ratio and smooth muscle contractile function in resistance arteries from patients with residual cardiovascular disease

M. Bloksgaard1, S. Möller2, T. Leurgans1, A. Irmukhamedov3, L. P. Riber3, Y. Wang4, J. G. De Mey1,3

Proc Physiol Soc 41 (2018)

Disruption of the smooth muscle actin cytoskeleton decreases human resistance artery stiffness and abolishes smooth muscle contractile function

M. Bloksgaard1, M. Morales-Quinones2, L. Martinez-Lemus2

Proc Physiol Soc 41 (2018)

Influence of muscle mass on capillarity and fibre composition in fast muscles of inbred and wild type rats

M. H. Nazir1, S. Egginton1

Proc Physiol Soc 41 (2018)

The Hedgehog Signalling pathway: insights from flies and fish

P. W. Ingham1,2

Proc Physiol Soc 40 (2018)

How much less would we understand about human physiology if we didn't use the mouse as a research model?

E. J. Cartwright1

Proc Physiol Soc 40 (2018)

Of mice, rats and men: using rodent models and human stem cell models to understand cellular and behavioural deficits in monogenic neurodevelopmental disorders

D. J. Wyllie1,2,3

Proc Physiol Soc 40 (2018)

The fish within - remodelling the pharynx in development and evolution

A. Graham1

Proc Physiol Soc 40 (2018)

Birds as model systems to understand the evolution of physiological control of behaviour.

T. V. Smulders1

Proc Physiol Soc 40 (2018)

Modelling the insect flight motor using in vivo, time-resolved microtomography

S. Walker1

Proc Physiol Soc 40 (2018)

Sodium nitroprusside prevents glucose-induced impairment of cerebrovascular development and function in zebrafish

K. Chhabria1, C. Howarth2, T. Chico1

Proc Physiol Soc 40 (2018)

Fish as models for extreme cardiac (patho)physiology

S. Egginton1

Proc Physiol Soc 40 (2018)

A systems approach to skeletal muscle adaptation

C. E. Stewart1

Proc Physiol Soc 40 (2018)

Replicating human disease in rodents: the good and the bad of CRISPR/Cas9 genome editing

G. Pavlovic1,2,3

Proc Physiol Soc 40 (2018)

A Quantitative Systems Pharmacology Approach to Understanding Drug Mechanisms of Action

A. E. Roashan1,2, A. Bithell1, M. Tindall2, M. Bazelot3, B. Whalley3, W. Hind3, R. Gray3, J. Brodie3

Proc Physiol Soc 40 (2018)

Seasonal and circadian contributions to mental health and wellbeing in the UK Biobank cohort

L. Lyall1, C. A. Wyse2, A. Ferguson1, N. Graham1, D. M. Lyall1, B. Cullen1, C. A. Celis Morales3, S. M. Biello4, D. Mackay1, J. Ward1, R. J. Strawbridge1, A. M. Curtis2, J. M. Gill3, M. E. Bailey5, J. P. Pell1, D. J. Smith1

Proc Physiol Soc 40 (2018)

From experiment to computational model and back: flipsides of the physiology coin

J. A. Jeneson1

Proc Physiol Soc 40 (2018)

My local AWERB - what's in it for me?

P. Hawkins1

Proc Physiol Soc 40 (2018)

Cardiovascular & renal disease insights from the rat

R. Menzies1

Proc Physiol Soc 40 (2018)

Using zebrafish to model joint physiology in development, ageing and disease

C. Hammond1

Proc Physiol Soc 40 (2018)

Towards human kidneys in culture: the power and limitations of self-organization

J. A. Davies1

Proc Physiol Soc 40 (2018)

Cutaneous photoageing: Systems for modelling repair of human skin

R. E. Watson1

Proc Physiol Soc 40 (2018)

Exploring the regulation of materno-fetal resource allocation and its implication for development, physiology and disease

A. Sferruzzi-Perri1

Proc Physiol Soc 40 (2018)

In vitro modelling of respiratory infection in cystic fibrosis related diabetes

E. R. Mavin1, B. Verdon2, J. Powell1, J. Roberts1, D. Baines3, C. Ward1,2, J. Garnett4,1

Proc Physiol Soc 40 (2018)

P130Cas regulates both venous endothelial angiogenesis in the caudal vein plexus and lymphatic development in the trunk of zebrafish

L. Wisniewski1, J. Burr1, N. Lockwood2, L. Valdivia3, P. Frankel1

Proc Physiol Soc 40 (2018)

The assembly of a mass spectrometry-based library of the guinea pig proteome as a tool for physiology research

P. Palmowski1, R. Watson1, N. Europe-finner1, A. Treumann2, M. Taggart1

Proc Physiol Soc 40 (2018)

Spatial coding deficits in mouse models of dementia

T. Ridler1, K. G. Phillips2, A. Randall1, J. T. Brown1

Proc Physiol Soc 40 (2018)

Adult myocardial slices: a viable and highly functional platform to bridge the gap between in vitro and in vivo cardiac studies.

F. Perbellini1, S. A. Watson1, J. Duff1, I. Bardi1, C. M. Terracciano1

Proc Physiol Soc 40 (2018)

The regenerating zebrafish heart following cryoinjury: role for neuropilin 1 in epicardial activation and revascularisation.

V. Lowe2, L. Wisniewski1, J. Sayers1, I. Zachary1, C. Pellet-Many1

Proc Physiol Soc 40 (2018)

Consequences of glycocalyx destruction on renal hemodynamics and oxygen consumption in healthy rats

E. Innes2, D. Souto Patinha2,1, M. Koeners2,1

Proc Physiol Soc 40 (2018)

Male AKR1D1 (5β-reductase) knockout mice have altered pancreatic islet morphology and hormone secretion

S. Harris1, L. Gathercole1,2, R. Ramracheya1, A. Forhead2,3, J. Tomlinson1

Proc Physiol Soc 40 (2018)

Hypothyroidism induces hyperplasia of unilocular adipocytes in perirenal adipose tissue of the ovine fetus

S. Harris2,1, M. J. De Blasio3, F. Wooding3, D. Blache4, A. Fowden3, A. Forhead2,3

Proc Physiol Soc 40 (2018)

Defining an efficient model for inducing obesity and metabolic syndrome in Wistar rats

T. G. Adedeji1, A. A. Fasanmade2, E. O. Olapade-Olaopa3

Proc Physiol Soc 40 (2018)

C. elegans as a model for biology in space

M. Cooke2,1, C. Deane1, A. pollard2, B. Philips2, T. Etheridge1, N. Szewczyk2

Proc Physiol Soc 40 (2018)

Purinergic modulation of cell proliferation within the spinal cord stem cell niche

C. Maclean1, J. Deuchars1, S. Deuchars1

Proc Physiol Soc 40 (2018)

Live Imaging of a Zebrafish Model to Investigate Mechanisms Underlying Foreign Body Reaction

K. French1,2, D. Gurevich1, J. Collin3,1, P. Martin1,4

Proc Physiol Soc 40 (2018)

Impairments in neural correlates of contextual memory in a mouse model of amyloidopathy

M. Garcia Garrido1, T. Ridler1, J. Terry2, J. T. Brown1

Proc Physiol Soc 40 (2018)

The effects of TNF-α and IL-1β on cardiac cellular calcium handling and contractility

N. Hadgraft1, D. J. Greensmith1

Proc Physiol Soc 40 (2018)

Stress and altered pubertal timing: is the limbic brain the key?

D. A. Ivanova1, C. McIntyre1, X. Li1, K. O'Byrne1

Proc Physiol Soc 40 (2018)

Long term study of renovascular hypertension: renal oxygenation, blood flow and sympathetic nerve activity

D. Souto Patinha1,2, M. Koeners1,2

Proc Physiol Soc 40 (2018)

Novel electromechanical method for measuring toxic response in aquatic invertebrates

A. M. Whiteoak1, P. Penson1

Proc Physiol Soc 40 (2018)

Of Mice and Men to "Animal Farm": Selecting animal models based on homologous protein primary sequences?

H. A. Widmer1, S. F. Cruickshank1, I. C. Rowe1, A. Strath1

Proc Physiol Soc 40 (2018)