Childhood exercise can reverse negative health effects caused by father’s obesity

8 November 2018   Exercise in childhood has been shown to promote long-lasting health and can counteract the risk of developing diabetes that comes from having an obese father.

That’s according to new research published in The Journal of Physiology. Insulin is a hormone that controls blood sugar levels and people with low insulin sensitivity do not respond to insulin as well as normal, which results in blood sugars levels increasing. This can lead to type 2 diabetes.

Children of fathers with a high-fat diet or who are obese are more likely to have low insulin sensitivity. This new research indicates that exercise early in life reverses the negative effect of this low insulin sensitivity in adulthood for children and therefore can counteract the risk of diabetes. 

The study conducted by Victoria University, Melbourne, in collaboration with the University of Melbourne, involved breeding obese male rats with healthy female rats. Their offspring underwent exercise training for only 4 weeks after weaning and then were assessed as adults in terms of responsiveness to glucose and insulin, skeletal muscle function and pancreas structure.

The offspring of obese fathers had reduced whole body and skeletal muscle insulin sensitivity and reduced insulin secretion. Early exercise in these offspring prevented in adulthood the negative effects caused by a high-fat diet in their fathers. It is important to note early exercise did not have any positive effects on their pancreas. This was very interesting as the group had previously shown that rats born small for gestational age, like humans, had pancreas problems as adults but in this case, early life exercise in the rats prevented the pancreatic problems. 

The study is limited in that the researchers did not determine at which age the alterations in the health status of the individual begins and when these changes take place. This would help to determine optimal periods during childhood when preventive interventions should be introduced. 

The researchers plan to look at which genes are switched on and off to determine the relationship between paternal diet and offspring exercise, as well as how exercise and paternal diet can affect the offspring’s physiology. They also plan to examine if similar effects occur in larger mammals that have developmental rates more similar to humans. 

Dr Filippe Falcão-Tebas, the first author, and Professor Glenn McConell, the senior author on the study, commented on the findings ‘Obesity due to a high-fat diet in the father can have a negative effect on the metabolism of their offspring. Our study showed that exercise only in early life of the offspring can have long-lasting beneficial effects on their health by normalizing their muscle insulin sensitivity in adulthood. Further work needs to be carried out including understanding what genes are switched on and off to cause these changes’. 

ENDS

Notes for Editors

1. Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by paternal high fat diet: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP276386

2. The Journal of Physiology publishes advances in physiology which increase our understanding of how our bodies function in health and disease. http://jp.physoc.org 

3. The Physiological Society brings together over 3,500 scientists from over 60 countries. The Society promotes physiology with the public and parliament alike. It supports physiologists by organising world-class conferences and offering grants for research and also publishes the latest developments in the field in its three leading scientific journals, The Journal of Physiology, Experimental Physiology and Physiological Reports. www.physoc.org 

 

Contacts:

The Physiological Society: 
Andrew Mackenzie, Head of Policy and Communications
+44 (0)20 7269 5728 

Corresponding author:

Filippe Falcão-Tebas