Cardiac power output (CPO) is a descriptor of cardiac function, calculated from the product of mean arterial blood pressure and cardiac output. Previous studies (Bain et al. 1990) have suggested that maximum cardiac power output (CPOpeak) and the ability to increase cardiac power output on stimulation are good descriptors of functional cardiac reserve. The normal range for CPOpeak has yet to be determined and the purpose of this study is to establish this in healthy adults. The study also examined the relationship between CPOpeak and peak oxygen consumption rate (VO2,peak) in the same population. After obtaining ethical approval and informed consent, 59 healthy adults (31 males and 28 females, means ± S.D.: age 43 ± 13 years, mass 74 ± 13 kg) completed an incremental exercise test to volitional fatigue using the protocol described by Bruce et al. (1973). VO2,peak was assessed on a breath-by-breath basis by online expiratory gas analysis (CardiO2, Medical Graphics Corp., St Paul, MN, USA). Having established each subject’s VO2,peak, and following a 40 min recovery period, cardiac output was measured at peak exercise (Qcpeak) using the non-invasive CO2 rebreathing method described by Defares (1958). During this second procedure, subjects attained a mean oxygen consumption rate of 101 ± 7 % of the VO2,peak achieved in the previous test. CPOpeak, in Watts (W), was then computed using the equation described by Cooke et al. (1998). Mean ± S.D. values for the variables investigated were: VO2,peak = 2.47 ± 0.7 l min-1, QTpeak = 18.3 ± 4.5 l min-1, and CPOpeak = 4.7 ± 1.3 W. The relationship between VO2,peak and CPOpeak was assessed by the Pearson product moment correlation coefficient. Analysis revealed a strong (r = 0.91, P < 0.01) correlation between the two variables. CPOpeak ranged from 3.80 to 7.94 W in men and 2.53 to 5.57 W in women. Although the sample size remains moderate, the cardiac power output values attained were normally distributed and these values provide a useful indication of the normal range for CPOpeak in healthy adults.
University College London (2003) J Physiol 547P, PC77
Poster Communications: Peak cardiac power output: physiological range and relationship to peak oxygen uptake in healthy adults
P.D. Bromley, L.D. Hodges and D.A. Brodie
Research Centre for Health Studies, Buckinghamshire Chilterns University College, Gorelands Lane, Buckinghamshire HP8 4AD, UK
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Where applicable, experiments conform with Society ethical requirements.