The high rates of firing at many synapses require mechanisms to replace the released neurotransmitter. At excitatory synapses (and probably many inhibitory synapses as well), this involves recycling through supporting glial cells and the intermediate glutamine. Transport systems N and A exhibit properties that suggest important roles in this cycle. An unrelated family of proteins contributes to the loading of synaptic vesicles with glutamate in the final step of the cycle
University of Newcastle (2003) J Physiol 549P, SA4
Research Symposium: The glutamine-glutamate cycle
R.T. Fremeau Jr, J. Burman, T. Qureshi, C.H. Tran, J. Johnson, H. Zhang, D. Sulzer, D.R. Copenhagen, J. Storm-Mathisen, R.J. Reimer, F.A. Chaudhry and R.H. Edwards
Departments of Neurology and Physiology, UCSF School of Medicine, 513 Parnassus Ave., SF, CA 94143-0435, USA
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