The demonstration will outline some of the ways that Human Patient Simulators (or manikins) will be used to enhance our existing physiology practical teaching. The latter is currently based largely on undergraduates recording their own physiological responses (e.g. blood pressure, ECG, static and dynamic lung volumes, alveolar gas composition, urine output) in situations that are well within their physiological limits. The manikin, on the other hand, can be programmed to simulate a wide range of physiological and pathophysiological processes and responses. These include: temperature changes; breathing (including the automatic and physiologically appropriate physical exchange of oxygen and carbon dioxide); cardiovascular parameters (for example electrocardiogram, cardiac output, systemic and pulmonary arterial pressure, central venous pressure); and respiratory parameters (for example arterial oxygen saturation and the partial pressures of oxygen & carbon dioxide in alveolar air and arterial blood). It can be used to model physiological responses to extreme environments, intense exercise and ageing as well as a wide range of pathophysiology including haemorrhage, shock and disease processes. All these scenarios can be used to reinforce and enhance understanding of basic physiological processes but cannot be imposed on students!