Whole blood stored in blood bags with anticoagulants in the blood banks and the condition of the blood determines its viability for transfusion (Duta, 2006). The loss of essential components of blood during storage is still a major problem in our environment. Commonly used anticoagulants are known to have effects on the quality of blood (Bailey and Dove, 1975; Kyou, 1990). We investigated the haematological, biochemical and physical changes during blood storage using the three different blood bags namely: ACD, CPD and CPDA1 bags. Venous blood obtained from 15 apparently healthy male volunteers (18 – 50 years old) divided into 3 groups of 5 males were placed into ACD, CPD and CPDA1 blood bags respectively. The haematological, biochemical and physical profile of the stored blood were determined using standard procedures at weekly intervals for 35 days. The results showed that the red cell indices (Hb concentration, red cell mass, haematocrit, MCV, MCH, MCHC) as well as biochemical parameters declined gradually in ACD while blood showed physical deterioration. In the CPD bags, the profiles showed better integrity while in the CPDA1 bags, no change occurred as the integrity of the parameters were well maintained through out the period of study (p<0.05). It is concluded that blood stored in CPDA1 bags had a greater viability, initial survival, long life of red blood cells, preservation and net loss of intracellular potassium ions was less. The specific gravity and the integrity of 2, 3 DPG were maintained. No physical deterioration was observed in the Blood stored in CPDA1 bags as compared with the ACD and CPD bags. CPDA1 anticoagulant bags should be recommended as the bag of choice.