OBJECTIVE: Our previous studies indicated that infraslow brain potential oscillations (ISO) in sensory cortical areas of rodents were involved in neuroprocessing of sensory information. The aim of this study was to analyze brain ISO over the projections of visual, auditory, and gustatory cortices in volunteers during application of corresponding sensory stimuli. METHODOLOGY: This work was conducted in adherence with the World Medical Association’s Declaration of Helsinki. Fifteen volunteers with the age of 24-41 (n=30 experiments) were included in this study. Surface Ag/AgCl electrodes were placed in the positions Fp1, T3, and O1 in accordance with 10-20 EEG scheme. ISO were recorded using computer EEG data acquisition/stimulation system. ISO were recorded over projections of visual cortex under condition of darkness (0 lx) and during rhythmic photic stimulation (0-1500 lx, 5 Hz, flash duration 40 ms); over projections of auditory cortex under condition of silence and during rhythmic acoustic stimulation (clicks, 40 dB SPL, 1000 Hz tone); over projections of frontal cortex under application of distilled water, 0.55 M glucose and 0.155 M NaCl solutions. Power spectral analysis was used to evaluate ISO dynamics, for statistics we used one-way ANOVA, and an alpha level of P<0.01 was adopted for all significance tests. RESULTS: There were found complex ISO dynamics in Fp1, T3, and O1 in all recordings, this consisted of: waves in the domain of seconds (0.1-0.25 Hz), multisecond oscillations (0.0167-0.035 Hz), fluctuations in the range of minutes (<0.004 Hz) and millivolt scale potential (+/-20 mV). Statistically significant spectral alterations (as increase of powers of waves in the domain of seconds) were detected in O1 and T3 recordings under rhythmical photic and acoustic stimulations, respectively (compared to ISO dynamics under the condition of darkness and silence there). Stimulus-dependent taste ISO responses were identified in Fp1 recordings again in the range of seconds. There were present clear multisecond oscillation changes (however, different and opposite in their directions in O1, T3, and Fp1 recordings) under exposure of visual, acoustic and gustatory stimuli, although we have not found any statistically significant changes of fluctuations in the domain of minutes and millivolt scale potential under all experimental conditions. CONCLUSIONS: Obtained data are strikingly similar to what was documented by us in rodents. Altogether, these allow us to conclude that infraslow brain potentials of different frequency domains reflect various neurophysiologic mechanisms of sensory information neuroprocessing in the human brain. Possible clinical implications of these results and this methodology should be strongly considered.