Oxidative stress plays an important role in the pathophysiology of cardiovascular disease. Studies show that sarcoidosis increases oxidative stress. High oxidative stress favors oxidative modification of low density lipoprotein (LDL) . The oxidation of LDL in the artery wall is belived to be primary event leading to the initiation and progression of atherosclerosis. Noninvasive ultrasound techniques are used to evaluate vascular system and cardiovascular condition. One such technique, pulse wave velocity (PWV) is defined as arterial pulse’s velocity of moving along the vessel wall, as an indicator of arterial elasticity. Oxidized LDL may impair arterial function and lead to an increase in arterial PWV. This study aims to investigate arterial distensibility using carotid-femoral (aortic) PWV measurements in patient with sarcoidosis. We recruited 19 patients (12 women, 7 men) with sarcoidosis, and 19 sex-matched healthy controls. In all groups carotid-femoral PWV was measured. PWV was determined by using an automatic device, the Complior Colson which allowed on-line pulse wave recording and automatic calculation of PWV. Triglyseride, total cholesterol, low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol, high density lipoprotein (HDL) cholesterol, oxidized LDL, homocysteine, high-sensitivity C-reactive protein (hs-CRP) levels determined. The association with carotid-femoral PWV and current biochemical parameters had been searched. All the values were expressed as means ± S.D. The obtained results were assesed by independent samples test. Correlations were calculated with the Pearson test. Carotid-femoral PWV, LDL cholesterol and hs-CRP were higher in patient with sarcoidosis than in control subjects (p=0.04, p=0.02, p=0.04 respectively) . There was no significantly change in triglyceride, total, VLDL, HDL cholesterol, oxidized LDL and homocysteine levels. There was a significant correlation between PWV and both total cholesterol (p=0.002, r=0.47) and LDL cholesterol (P=0.001, r=0.51). PWV is influenced by total cholesterol, LDL cholesterol. Patient with sarcoidosis must be followed closely for arterial stiffness.