OBJECTIVE: It was shown in our previous works the presence infraslow brain potential oscillations (ISO) in primary visual (V1), auditory (A1) and gustatory (G1) cortical areas, as also we demonstrated ISO implication in CNS mechanisms of sensory information processing. However, the processes of cortical ISO modulation are little known. The aim of this study was to find how the dynamics of ISO is modulated in V1, A1, and G1 by the influences of locus coeruleus (LC), dorsal raphe nucleus (DRN), and nucleus basalis magnocellularis (NBM), that send noradrenergic, serotoninergic and cholinergic projections, respectively, to neocortex. METHODS: Experiments were guided by European Parliament and Council Directive (2010/63/EU) on the protection of animals used for scientific purposes. All experiments were performed on 30 (n=75 experiments) adult albino rats anesthetized by urethane (0.7 g/kg, i.p.) with stereotaxic electrodes implanted to V1, A1, G1; LC, DRN, and NBM. The recordings of ISO from these structures were obtained before and after successive electrical stimulation of aforementioned brain nuclei. The positions of electrodes were verified morphologically. ISO recordings were analyzed by means of power spectral analysis and statistical significances of differences were evaluated using one-way ANOVA (an alpha level of 0.05 was adopted for all significance tests). RESULTS: It was detected that before electrostimulation of LC, DRN, and NBM, multisecond ISO were correlated between these nuclei and aforementioned cortical sites (0.44<r<0.66). We found that electrical stimulation of LC, DRN and NBM induced statistically significant alterations of ISO in V1, A1 and G1, these changes were manifested as specific power patters of ISO in the domain of seconds (0.1-0.3 Hz) and multisecond waves (0.0167-0.043 Hz) without any alterations of dynamics of fluctuations in the range of minutes (<0.0167 Hz). Each cortical site (e.g. V1, A1, G1) responded to the activation of LC, DRN, NBM by specific power spectral pattern configuration in the range of seconds and dozens of seconds, as also each neurotransmitter center (e.g. LC, DRN, NBM) influenced on ISO neurodynamics of different cortical sites in a highly specific way. CONCLUSIONS: Based on obtained results, it is possible to conclude that activation of noradrenergic (LC), serotoninergic (DRN) and cholinergic (NBM) systems of the brain have different but specific and powerful effects on neuromodulation of ISO dynamics in the primary sensory cortical areas. We assume that such pre-tuning of ISO in the primary cortical sensory areas by different neurotransmission systems plays an important role for further optimal sensory information processing background.