The Protective effect of melanin from White Silky Fowl on on rat model of Parkinson’s disease (PD) induced by 6-Hydroxydop (6-OH DA) were studied. PD model were induced by unilateral intrastriatal injection of 6-OH DA to destroy the nigrostriatal dopamine system in the rat (all the operation were performed on anaesthetised rats). The apomorphine-induced rotation test was applied to screen out parkinsonism rats after 5 weeks operation. The melanin (6 or 20mg/Kg) were used on Parkinsonism rats by intragastric administered per day for 4 weeks, normal saline administration as control group. After the 3 and 4weeks drug administration, the rats were detected by rotation test and open-field Test. The results were as shows: In rotation test, 6mg/Kg melanin administration could reduce the rotation movement at 4 weeks significantly and 20mg/Kg melanin administration reduced the rotation at 3 and 4 weeks. In open-field Test, 20mg/Kg melanin administration could increase the loco motor distance of Parkinsonism rats at 4 weeks significantly. Therefore, melanin in White Silky Fowl could be a novel drug candidate for treatment of PD. Key words: melanin from white silky fowl; Parkinson’s disease ; 6-Hydroxydopa